Detailed information of TA system TA234200

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 1210955..1212705
• Replicon: chromosome
• Accession: NZ_CP091647
• Organism: Burkholderia aenigmatica strain CMCC(B)23010

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: L3V59_RS23505
• Protein ID: WP_175025852.1
• Coordinates: 1211809..1212705 (-)
• Length: 299 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: L3V59_RS23500
• Protein ID: WP_226213534.1
• Coordinates: 1210955..1211812 (-)
• Length: 286 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L3V59_RS23480 (L3V59_23480)	1206130..1207620	-	1491	WP_237435253.1	aldehyde dehydrogenase	-
L3V59_RS23485 (L3V59_23485)	1207693..1208508	-	816	WP_122947445.1	aspartate dehydrogenase	-
L3V59_RS23490 (L3V59_23490)	1208501..1210168	-	1668	WP_237435254.1	thiamine pyrophosphate-binding protein	-
L3V59_RS23495 (L3V59_23495)	1210161..1210958	-	798	WP_122947447.1	SDR family oxidoreductase	-
L3V59_RS23500 (L3V59_23500)	1210955..1211812	-	858	WP_226213534.1	IclR family transcriptional regulator	Antitoxin
L3V59_RS23505 (L3V59_23505)	1211809..1212705	-	897	WP_175025852.1	alpha/beta fold hydrolase	Toxin
L3V59_RS23510 (L3V59_23510)	1212724..1213251	-	528	WP_043177345.1	cupin domain-containing protein	-
L3V59_RS23515 (L3V59_23515)	1213289..1214017	-	729	WP_237435255.1	SDR family oxidoreductase	-
L3V59_RS23520 (L3V59_23520)	1214051..1215127	-	1077	WP_039344090.1	aromatic ring-hydroxylating dioxygenase subunit alpha	-
L3V59_RS23525 (L3V59_23525)	1215180..1215491	-	312	WP_237435256.1	hypothetical protein	-
L3V59_RS23530 (L3V59_23530)	1215493..1215810	-	318	WP_006758060.1	non-heme iron oxygenase ferredoxin subunit	-
L3V59_RS23535 (L3V59_23535)	1216255..1217334	+	1080	WP_226213537.1	porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (51-279)

Antitoxin

• Transcription regulator IclR, N-terminal (24-72)

Sequences

Toxin

Protein

• Length: 299 a.a.
• Molecular weight: 30718.96 Da
• Isoelectric Point: 8.0625

>T234200 WP_175025852.1 NZ_CP091647:c1212705-1211809 [Burkholderia aenigmatica]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAATDYAASLNAWLEALGIERCVLVGHSLGAIIAGGLARVMPARIAGLLLVSPAGGYGSAPAETR
ESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEDARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDTFCRQCDQQRGLA

Nucleotide

• Length: 897 bp

>T234200 NZ_LR027873:938935-939228 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAAGTGTACTTAAAAGAGTTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCGTCACTTCAAGCCGACCAAAGCGAAAGTAACGCATAG

Antitoxin

Protein

• Length: 286 a.a.
• Molecular weight: 31309.80 Da
• Isoelectric Point: 6.5058

>AT234200 WP_226213534.1 NZ_CP091647:c1211812-1210955 [Burkholderia aenigmatica]
MNEPLQQPDSENGKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGALNRMTSATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Nucleotide

• Length: 858 bp

>AT234200 NZ_LR027873:938723-938932 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA