Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 207890..208467 Replicon chromosome
Accession NZ_CP091647
Organism Burkholderia aenigmatica strain CMCC(B)23010

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L3V59_RS19070 Protein ID WP_174956523.1
Coordinates 207890..208255 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L3V59_RS19075 Protein ID WP_089427770.1
Coordinates 208249..208467 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3V59_RS19050 (L3V59_19050) 203698..204252 + 555 WP_174956526.1 carboxymuconolactone decarboxylase family protein -
L3V59_RS19055 (L3V59_19055) 204413..205192 + 780 WP_237434738.1 extensin -
L3V59_RS19060 (L3V59_19060) 205288..206886 - 1599 WP_122949394.1 alkyl hydroperoxide reductase subunit F -
L3V59_RS19065 (L3V59_19065) 207015..207578 - 564 WP_237434739.1 alkyl hydroperoxide reductase subunit C -
L3V59_RS19070 (L3V59_19070) 207890..208255 - 366 WP_174956523.1 type II toxin-antitoxin system VapC family toxin Toxin
L3V59_RS19075 (L3V59_19075) 208249..208467 - 219 WP_089427770.1 CopG family transcriptional regulator Antitoxin
L3V59_RS19080 (L3V59_19080) 208557..209453 - 897 WP_011355549.1 LysR substrate-binding domain-containing protein -
L3V59_RS19085 (L3V59_19085) 209631..210797 + 1167 WP_237434740.1 branched-chain amino acid ABC transporter substrate-binding protein -
L3V59_RS19090 (L3V59_19090) 210831..211355 + 525 WP_237434741.1 L-2-amino-thiazoline-4-carboxylic acid hydrolase -
L3V59_RS19095 (L3V59_19095) 211348..212619 + 1272 WP_237434742.1 Zn-dependent hydrolase -
L3V59_RS19100 (L3V59_19100) 212712..213191 - 480 WP_237434743.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13492.53 Da        Isoelectric Point: 7.0113

>T234198 WP_174956523.1 NZ_CP091647:c208255-207890 [Burkholderia aenigmatica]
MVKALFDTNILIDYLGGVESARTELGRYDYRAISTISWMEVLVGTSAHSEAAMRVWLSSFDVIALDNAVANRAVTIRQER
RIRLPDAIVWASAQVNGLLLVSRNIKDFPATEPGVRVPYQI

Download         Length: 366 bp

>T234198 NZ_LR027870:c2578531-2578265 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8266.38 Da        Isoelectric Point: 4.5720

>AT234198 WP_089427770.1 NZ_CP091647:c208467-208249 [Burkholderia aenigmatica]
MSRILVDLSNGQLDELAAIVETERRPRAAIIRDAIDAYIALHKRPLADDVFGLWKDRTVDGLAYQEELRSEW

Download         Length: 219 bp

>AT234198 NZ_LR027870:c2578788-2578531 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References