Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 153942..154588 Replicon chromosome
Accession NZ_CP091647
Organism Burkholderia aenigmatica strain CMCC(B)23010

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L3V59_RS18805 Protein ID WP_122949353.1
Coordinates 154181..154588 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A3G3HIS6
Locus tag L3V59_RS18800 Protein ID WP_043179333.1
Coordinates 153942..154184 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3V59_RS18785 (L3V59_18785) 149957..151363 + 1407 WP_237434710.1 aspartate ammonia-lyase -
L3V59_RS18790 (L3V59_18790) 151471..152982 + 1512 WP_175221570.1 amino acid permease -
L3V59_RS18795 (L3V59_18795) 153044..153727 - 684 WP_237434711.1 phospholipase -
L3V59_RS18800 (L3V59_18800) 153942..154184 + 243 WP_043179333.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L3V59_RS18805 (L3V59_18805) 154181..154588 + 408 WP_122949353.1 type II toxin-antitoxin system VapC family toxin Toxin
L3V59_RS18810 (L3V59_18810) 154647..156134 - 1488 WP_237434712.1 aldehyde dehydrogenase -
L3V59_RS18815 (L3V59_18815) 156163..156741 - 579 WP_237434713.1 thioesterase family protein -
L3V59_RS18820 (L3V59_18820) 157014..158144 + 1131 WP_174956554.1 porin -
L3V59_RS18825 (L3V59_18825) 158375..159130 - 756 WP_237434714.1 acetate--CoA ligase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14912.08 Da        Isoelectric Point: 6.2320

>T234197 WP_122949353.1 NZ_CP091647:154181-154588 [Burkholderia aenigmatica]
MKFLLDTNAVIAIMKGEPAMLARLRTYQPADFGMPAIVAHELYYGAYKSQRAAANVARVEALQFEVVSFDAEDAQHAGAI
RAQLTAAGTPIGPYDALIAGQARARRLVLVTHNMREFSRVPELQVEDWLAEPREN

Download         Length: 408 bp

>T234197 NZ_LR027870:c2546950-2546843 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8918.06 Da        Isoelectric Point: 4.7628

>AT234197 WP_043179333.1 NZ_CP091647:153942-154184 [Burkholderia aenigmatica]
MDTAKIFKHGGSQAVRLPKDFRFETTEVRIRRHGSSVILEPVPQDWAWLTPLIGPVDADFEAAATTEPAAQERPGLDVFE

Download         Length: 243 bp

>AT234197 NZ_LR027870:2546766-2546826 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3G3HIS6

References