234196

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 2891204..2891826 Replicon chromosome
Accession NZ_CP091646
Organism Burkholderia aenigmatica strain CMCC(B)23010

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag L3V59_RS13700 Protein ID WP_175222859.1
Coordinates 2891204..2891503 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag L3V59_RS13705 Protein ID WP_175222860.1
Coordinates 2891503..2891826 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3V59_RS13675 (L3V59_13675) 2887494..2887736 - 243 WP_059530978.1 DUF3311 domain-containing protein -
L3V59_RS13680 (L3V59_13680) 2887935..2888852 - 918 WP_122945964.1 spermidine synthase -
L3V59_RS13685 (L3V59_13685) 2889230..2890273 + 1044 WP_237432738.1 hypothetical protein -
L3V59_RS13690 (L3V59_13690) 2890437..2890691 + 255 WP_237432739.1 hypothetical protein -
L3V59_RS13695 (L3V59_13695) 2890739..2890861 - 123 Protein_2670 DNA-deoxyinosine glycosylase -
L3V59_RS13700 (L3V59_13700) 2891204..2891503 + 300 WP_175222859.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L3V59_RS13705 (L3V59_13705) 2891503..2891826 + 324 WP_175222860.1 helix-turn-helix transcriptional regulator Antitoxin
L3V59_RS13710 (L3V59_13710) 2891913..2892026 - 114 Protein_2673 DNA-deoxyinosine glycosylase -
L3V59_RS13715 (L3V59_13715) 2892301..2893076 + 776 Protein_2674 ABC transporter substrate-binding protein -
L3V59_RS13720 (L3V59_13720) 2893135..2894250 + 1116 WP_237432740.1 M14 family metallopeptidase -
L3V59_RS13725 (L3V59_13725) 2894482..2894958 - 477 WP_175222863.1 DNA-deoxyinosine glycosylase -
L3V59_RS13730 (L3V59_13730) 2894958..2895554 - 597 WP_122946739.1 chorismate lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(1-89)

Antitoxin

HigA2-like, helix-turn-helix domain

(11-89)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 10844.46 Da        Isoelectric Point: 9.9172

>T234196 WP_175222859.1 NZ_CP091646:2891204-2891503 [Burkholderia aenigmatica]
MPEIVQDTFGYALYLARAGRKHDQAKPLKGFGSAGVLEVVESEDSGTYRAVYTVKLGHAVYVLHCFQKKSSRGIATPKRD
IDLVRDRLKAAEAHAKGAL

Download         Length: 300 bp

>T234196 NZ_LR027870:c2521669-2521403 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11758.61 Da        Isoelectric Point: 8.0703

>AT234196 WP_175222860.1 NZ_CP091646:2891503-2891826 [Burkholderia aenigmatica]
MIEIEPGSGNVYADLGMRDAEEMRVKAQLAAKIGEIVKTRQWTQQHAARVLGMTQPKLSNMLRGQFRGVSEAKMLECLAK
LGRDVQIVVGPDRHSGTEGHIEVVFAA

Download         Length: 324 bp

>AT234196 NZ_LR027870:c2521920-2521669 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References