Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1915649..1916325 Replicon chromosome
Accession NZ_CP091646
Organism Burkholderia aenigmatica strain CMCC(B)23010

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag L3V59_RS08985 Protein ID WP_089456196.1
Coordinates 1915909..1916325 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag L3V59_RS08980 Protein ID WP_122946671.1
Coordinates 1915649..1915912 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3V59_RS08965 (L3V59_08965) 1911206..1913458 + 2253 WP_122945329.1 TonB-dependent siderophore receptor -
L3V59_RS08970 (L3V59_08970) 1913544..1914383 + 840 WP_122946670.1 formyltransferase family protein -
L3V59_RS08975 (L3V59_08975) 1914383..1915399 + 1017 WP_122945330.1 GNAT family N-acetyltransferase -
L3V59_RS08980 (L3V59_08980) 1915649..1915912 + 264 WP_122946671.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L3V59_RS08985 (L3V59_08985) 1915909..1916325 + 417 WP_089456196.1 PIN domain-containing protein Toxin
L3V59_RS08990 (L3V59_08990) 1916374..1917279 - 906 WP_122945331.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
L3V59_RS08995 (L3V59_08995) 1917248..1918333 - 1086 WP_272931277.1 type IV toxin-antitoxin system AbiEi family antitoxin -
L3V59_RS09000 (L3V59_09000) 1918660..1919823 + 1164 WP_122945333.1 M20 aminoacylase family protein -
L3V59_RS09005 (L3V59_09005) 1920011..1920550 + 540 WP_089495289.1 outer membrane protein assembly factor BamE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14589.72 Da        Isoelectric Point: 7.9142

>T234195 WP_089456196.1 NZ_CP091646:1915909-1916325 [Burkholderia aenigmatica]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRADLAARGTPIGANDASIAGHAIAAGAVLVTHNSREFGRVAGLSLEDWAA

Download         Length: 417 bp

>T234195 NZ_LR027870:c2255214-2255110 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9718.99 Da        Isoelectric Point: 4.6310

>AT234195 WP_122946671.1 NZ_CP091646:1915649-1915912 [Burkholderia aenigmatica]
MRTVSIFKNARNQAIRIPKDMEFKGVTELEIRREGDTLLLRPVRPTWLSFGSEPLADADFLAERPAIIESGRFDLSDDGA
APTESGQ

Download         Length: 264 bp

>AT234195 NZ_LR027870:2255016-2255054 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References