Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 165079..165716 Replicon chromosome
Accession NZ_CP091646
Organism Burkholderia aenigmatica strain CMCC(B)23010

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L3V59_RS00740 Protein ID WP_237433065.1
Coordinates 165315..165716 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag L3V59_RS00735 Protein ID WP_122944105.1
Coordinates 165079..165315 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3V59_RS00720 (L3V59_00720) 160618..161652 + 1035 WP_175222270.1 helix-turn-helix domain-containing protein -
L3V59_RS00725 (L3V59_00725) 161920..163017 - 1098 WP_237433064.1 ADP-heptose--LPS heptosyltransferase -
L3V59_RS00730 (L3V59_00730) 163014..164717 - 1704 WP_226218125.1 thiamine pyrophosphate-binding protein -
L3V59_RS00735 (L3V59_00735) 165079..165315 + 237 WP_122944105.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L3V59_RS00740 (L3V59_00740) 165315..165716 + 402 WP_237433065.1 type II toxin-antitoxin system VapC family toxin Toxin
L3V59_RS00745 (L3V59_00745) 165783..167171 - 1389 WP_237433066.1 L-serine ammonia-lyase -
L3V59_RS00750 (L3V59_00750) 167202..168305 - 1104 WP_236027649.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14956.95 Da        Isoelectric Point: 4.4741

>T234194 WP_237433065.1 NZ_CP091646:165315-165716 [Burkholderia aenigmatica]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTTCASPARERGNLAALIDDIPVAPFDVAAAQA
YGPVREATRERKQDHLDKLIAAHAVSLDVVLVTNNERDFDSYPGLRLENWLDD

Download         Length: 402 bp

>T234194 NZ_LR027870:c2197850-2197641 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9036.14 Da        Isoelectric Point: 5.7316

>AT234194 WP_122944105.1 NZ_CP091646:165079-165315 [Burkholderia aenigmatica]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPARRPLTRVLEKFAQFGPDFMAEGRGDHEQAEREGL

Download         Length: 237 bp

>AT234194 NZ_LR027870:c2198155-2197862 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References