Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/MqsA(antitoxin) |
| Location | 8390..8883 | Replicon | plasmid p1063-3 |
| Accession | NZ_CP091638 | ||
| Organism | Salmonella enterica strain 1063 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | U9Y9W8 |
| Locus tag | L5504_RS23785 | Protein ID | WP_001230709.1 |
| Coordinates | 8390..8644 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | - |
| Locus tag | L5504_RS23790 | Protein ID | WP_268952991.1 |
| Coordinates | 8641..8883 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L5504_RS23745 (L5504_23750) | 3905..4057 | + | 153 | Protein_2 | DUF5431 family protein | - |
| L5504_RS23750 (L5504_23755) | 4005..4124 | + | 120 | WP_229002406.1 | Hok/Gef family protein | - |
| L5504_RS23755 (L5504_23760) | 4274..4870 | + | 597 | WP_000125165.1 | ProQ/FINO family protein | - |
| L5504_RS23760 (L5504_23765) | 4888..5172 | - | 285 | WP_001162371.1 | hypothetical protein | - |
| L5504_RS23765 (L5504_23770) | 5246..5911 | - | 666 | WP_000532149.1 | division plane positioning ATPase MipZ | - |
| L5504_RS23770 (L5504_23775) | 6499..6828 | + | 330 | WP_000855119.1 | hypothetical protein | - |
| L5504_RS23775 (L5504_23780) | 7232..7747 | + | 516 | WP_001025393.1 | J domain-containing protein | - |
| L5504_RS23780 (L5504_23785) | 7851..8393 | + | 543 | WP_001083904.1 | hypothetical protein | - |
| L5504_RS23785 (L5504_23790) | 8390..8644 | + | 255 | WP_001230709.1 | hypothetical protein | Toxin |
| L5504_RS23790 (L5504_23795) | 8641..8883 | + | 243 | WP_268952991.1 | XRE family transcriptional regulator | Antitoxin |
| L5504_RS23795 (L5504_23800) | 9454..9747 | + | 294 | WP_000673428.1 | hypothetical protein | - |
| L5504_RS23800 (L5504_23805) | 10164..10607 | - | 444 | WP_000192625.1 | hypothetical protein | - |
| L5504_RS23805 (L5504_23810) | 10904..11086 | + | 183 | WP_000833470.1 | type II toxin-antitoxin system HicA family toxin | - |
| L5504_RS23810 (L5504_23815) | 11111..11548 | + | 438 | WP_000466318.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| L5504_RS23815 (L5504_23820) | 11682..11867 | - | 186 | Protein_16 | hypothetical protein | - |
| L5504_RS23820 (L5504_23825) | 12002..12211 | - | 210 | WP_000951714.1 | hypothetical protein | - |
| L5504_RS23825 (L5504_23830) | 12213..12410 | - | 198 | WP_001439049.1 | hypothetical protein | - |
| L5504_RS23830 (L5504_23835) | 12416..12865 | - | 450 | WP_000206698.1 | hypothetical protein | - |
| L5504_RS23835 (L5504_23840) | 12885..13592 | - | 708 | WP_021503228.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | - | 1..59036 | 59036 | |
| - | flank | IS/Tn | - | - | 2296..3444 | 1148 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9942.47 Da Isoelectric Point: 10.1206
>T234173 WP_001230709.1 NZ_CP091638:8390-8644 [Salmonella enterica]
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA
Download Length: 255 bp
>T234173 NZ_LR027557:c5483136-5482954 [Pseudomonas synxantha]
GTGGATAGCCGCTATTTGATAGGTAACATCGTTGCAGACGGTTGGTATCTGGTGCGCATCAGGGGCAGTCATCATCACTT
CAAGCACCGGACAAAGCCCGGTCTGGTCACGATTCCTCATCCAAAAAAGGACCTGCTGGATAAAACCGCCAAGAGCATTT
TGAAACAGGCTCTGCTGAGTTAA
GTGGATAGCCGCTATTTGATAGGTAACATCGTTGCAGACGGTTGGTATCTGGTGCGCATCAGGGGCAGTCATCATCACTT
CAAGCACCGGACAAAGCCCGGTCTGGTCACGATTCCTCATCCAAAAAAGGACCTGCTGGATAAAACCGCCAAGAGCATTT
TGAAACAGGCTCTGCTGAGTTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9126.41 Da Isoelectric Point: 7.2775
>AT234173 WP_268952991.1 NZ_CP091638:8641-8883 [Salmonella enterica]
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEES
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEES
Download Length: 243 bp
>AT234173 NZ_LR027557:c5482931-5482521 [Pseudomonas synxantha]
ATGCTTTATCCCATCGCAATTTCAACGGGCGACGAGGACCACGCCTGGGGCGTGGAAGTCCCGGATATTCCCGGGTGCTA
TTCCGCCGGCGATGACCTGGACGACGCCATGGCCATGGCCCGCGAAGCCATCGAGGGGCACTTCGAGATCCTTGCAGAAG
ATGGCGCGCCGATCCCCAGTGCCCAGAAAGTCACCTTGCACGCCGCCAACCCACAGTACGCAGGCTGCACCTGGGCGGTG
GTAGACATCGACGTCACCAAGTACCTGGGCAAGGCGCAAAAACTCAACATCACCCTGCCGGGGTATCTGTTGAATCGCAT
CGATGACTATGTACTGAATCACCCGGAAGAAAAAAGCCGCTCGGGGTTTCTGGCGTCCGCGGCACTCAAGGTATTGCAAC
AGGATCGATAA
ATGCTTTATCCCATCGCAATTTCAACGGGCGACGAGGACCACGCCTGGGGCGTGGAAGTCCCGGATATTCCCGGGTGCTA
TTCCGCCGGCGATGACCTGGACGACGCCATGGCCATGGCCCGCGAAGCCATCGAGGGGCACTTCGAGATCCTTGCAGAAG
ATGGCGCGCCGATCCCCAGTGCCCAGAAAGTCACCTTGCACGCCGCCAACCCACAGTACGCAGGCTGCACCTGGGCGGTG
GTAGACATCGACGTCACCAAGTACCTGGGCAAGGCGCAAAAACTCAACATCACCCTGCCGGGGTATCTGTTGAATCGCAT
CGATGACTATGTACTGAATCACCCGGAAGAAAAAAGCCGCTCGGGGTTTCTGGCGTCCGCGGCACTCAAGGTATTGCAAC
AGGATCGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|