Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 88676..90299 Replicon plasmid p1063-MDR
Accession NZ_CP091637
Organism Salmonella enterica strain 1063

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag L5504_RS22635 Protein ID WP_000088046.1
Coordinates 88974..90299 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag L5504_RS22630 Protein ID WP_024136327.1
Coordinates 88676..88969 (+) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5504_RS22595 83746..83877 + 132 WP_000374059.1 hypothetical protein -
L5504_RS22600 (L5504_22605) 84218..84499 - 282 WP_000077926.1 hypothetical protein -
L5504_RS22605 (L5504_22610) 84549..84740 - 192 WP_000398480.1 hypothetical protein -
L5504_RS22610 (L5504_22615) 84964..86136 + 1173 WP_000952349.1 IS21-like element IS21 family transposase -
L5504_RS22615 (L5504_22620) 86136..86933 + 798 WP_000544828.1 IS21-like element IS21 family helper ATPase IstB -
L5504_RS22620 (L5504_22625) 86972..87307 - 336 WP_065311125.1 hypothetical protein -
L5504_RS22625 (L5504_22630) 87680..88072 + 393 WP_000341066.1 hypothetical protein -
L5504_RS22630 (L5504_22635) 88676..88969 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
L5504_RS22635 (L5504_22640) 88974..90299 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
L5504_RS22640 (L5504_22645) 90360..90566 + 207 WP_000134171.1 hypothetical protein -
L5504_RS22645 (L5504_22650) 90668..91078 + 411 WP_000985911.1 hypothetical protein -
L5504_RS22650 (L5504_22655) 91091..91906 + 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
L5504_RS22655 (L5504_22660) 92160..92585 + 426 WP_001043843.1 hypothetical protein -
L5504_RS22660 (L5504_22665) 93134..93442 + 309 WP_001224687.1 hypothetical protein -
L5504_RS22665 (L5504_22670) 93458..94315 + 858 WP_000784387.1 HNH endonuclease signature motif containing protein -
L5504_RS22670 (L5504_22675) 94377..94580 + 204 WP_001194555.1 hypothetical protein -
L5504_RS22675 (L5504_22680) 94922..95278 - 357 WP_065311124.1 H-NS family nucleoid-associated regulatory protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(3')-Ia / floR / qnrS13 / blaCTX-M-55 / blaTEM-1B / blaLAP-2 / aac(3)-IId / sul2 / ant(3'')-Ia / lnu(F) / sul3 / tet(A) / aph(6)-Id / ARR-3 / dfrA14 - 1..279202 279202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(9-108)

Antitoxin

(21-69)


Sequences


Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T234172 WP_000088046.1 NZ_CP091637:88974-90299 [Salmonella enterica]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T234172 NZ_LR027557:c3347323-3347141 [Pseudomonas synxantha]
ATGAGAAGTAGAGAGGTAATTGATCTGCTGGTTGCGGATGGATGGTTTGAGGTGGCGACAAAGGGCAGTCATCACCAGTT
CAAACATCCTATAAAGCGGGGGCGAGTGACCGTCCCTCATCCCAAGTCAGAGATTGCCAAAGGCACTTTGCATAGTATTT
TTAAATCAGCAGGGCTTAAGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT234172 WP_024136327.1 NZ_CP091637:88676-88969 [Salmonella enterica]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT234172 NZ_LR027557:c3347088-3346687 [Pseudomonas synxantha]
ATGAAATTTCCAGTGGTAGTACATAAAGATGCTGATTCGGATTACAGCGTAACAGTCCCTGATGTACCCGGTTGCTTCTC
GGCGGGCTCTTCGTTTTCCGAAGCGTTGGATAATGTACGGGAGGCGCTGGCGCTGCACCTCGAGGGGCTGGTTGCCGACG
AGGAAACCCTTCCGCAGGCGCAAGAGGTTGATGCTCATCTCGAAAATCCGGACTACGCCGGTGGTGTCTGGGCGATTGTT
GATTTTGATCTCGCGCCTTACTTGGGTAAGTCGGTACGGTTCAATGCTTCTTTACCCGAGCAGCTTCTACACCGGATTGA
CGAACGCGTGCAAAAAGATCATCGCTACGCTTCCCGATCAGGTTTTTTGGCGACGGCGGCGCTGCGTGAATTGTCCGCTT
GA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1


Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References