Detailed information of TA system TA234169

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3998163..3998679
• Replicon: chromosome
• Accession: NZ_CP091636
• Organism: Salmonella enterica strain 1063

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L5504_RS19130
• Protein ID: WP_133323120.1
• Coordinates: 3998163..3998447 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V7ISI8
• Locus tag: L5504_RS19135
• Protein ID: WP_000212724.1
• Coordinates: 3998437..3998679 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5504_RS19115 (3993375)	3993375..3995027	+	1653	WP_023137597.1	alpha,alpha-phosphotrehalase	-
L5504_RS19120 (3995436)	3995436..3997574	+	2139	WP_000187818.1	anaerobic ribonucleoside-triphosphate reductase	-
L5504_RS19125 (3997695)	3997695..3998159	+	465	WP_133323118.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
L5504_RS19130 (3998163)	3998163..3998447	-	285	WP_133323120.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L5504_RS19135 (3998437)	3998437..3998679	-	243	WP_000212724.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
L5504_RS19140 (3998757)	3998757..4000670	-	1914	WP_001212140.1	BglG family transcription antiterminator	-
L5504_RS19145 (4000687)	4000687..4001427	-	741	WP_023229489.1	KDGP aldolase family protein	-
L5504_RS19150 (4001424)	4001424..4002542	-	1119	WP_133323122.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
L5504_RS19155 (4002526)	4002526..4003659	-	1134	WP_133323124.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10926.73 Da
• Isoelectric Point: 9.8739

>T234169 WP_133323120.1 NZ_CP091636:c3998447-3998163 [Salmonella enterica]
MTYELEFDPRALKEWHKLDDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T234169 NZ_LR027557:1481174-1481524 [Pseudomonas synxantha]
ATGGATGCTCTATTTATCGAACTGCCGGCATTCGAGCGGCATCGCAAGGACTATCTGAGTGAGGAGCTTTTCCAGGGTTT
TCAACAGGAGTTAATGAAAAACCCCGAAGCAGGAGATGTGATCGAAGGAACGGGCGGGTTGAGAAAGGTTCGCTTCGTTG
ATGAAAGGCGAAACAAAGGCAAGCGTGGTGGCCTGCGAGTCATTTACTACTGGTGGTCAGGCGGCACGCAATTCTGGTTA
TTCACCTTGTACGGCAAGCACGAACAGAGCGACCTGACACCCCACCACAAGAAAGCTCTTAAACACATGCTGGACAGGGA
AATCAAAGCGAGAACACATCATGAAACGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT234169 WP_000212724.1 NZ_CP091636:c3998679-3998437 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT234169 NZ_LR027557:1481514-1481828 [Pseudomonas synxantha]
ATGAAACGTGACATCTTTTCCGAACTGGTCGAAGGCTTCGACGCCCTGGCCGATGAGCGCCAGGGTAAAATCACCCTGCG
CAACCACAAGGTCCACCTTAACAAGCTGGCGCCGCTCACCGCTGATGAGGTGATCGCCGTGCGCCAGCAACTCAACCTTT
CCCGGTCGGTATTCGCCATGTACCTGCGTACCAACACCCGCACCCTGGAGAACTGGGAACAAGGCCGGGCCAAGCCCAAC
GCCCAGGCCGTCACCCTGATCCGTCTGGTAGCGCGTTTTCCTGAAACCGTGGCGCAACTTGCCGCATTGGGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A5H5JRI5