Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 213392..214152 Replicon chromosome
Accession NZ_CP091636
Organism Salmonella enterica strain 1063

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag L5504_RS01005 Protein ID WP_000533909.1
Coordinates 213667..214152 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag L5504_RS01000 Protein ID WP_000965889.1
Coordinates 213392..213679 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5504_RS00980 (208738) 208738..210066 - 1329 WP_000200570.1 MFS transporter -
L5504_RS00985 (210254) 210254..211414 - 1161 WP_000107288.1 mandelate racemase/muconate lactonizing enzyme family protein -
L5504_RS00990 (211520) 211520..212419 + 900 WP_000462482.1 LysR family transcriptional regulator -
L5504_RS00995 (212556) 212556..213209 - 654 WP_001139163.1 LysE family translocator -
L5504_RS01000 (213392) 213392..213679 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
L5504_RS01005 (213667) 213667..214152 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
L5504_RS01010 (214524) 214524..215063 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
L5504_RS01015 (215237) 215237..215449 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
L5504_RS01020 (215737) 215737..216027 - 291 WP_000455790.1 HTH-type transcriptional regulator -
L5504_RS01025 (216466) 216466..217176 + 711 WP_000190524.1 DUF3053 domain-containing protein -
L5504_RS01030 (217226) 217226..218200 - 975 WP_000804681.1 glyoxylate/hydroxypyruvate reductase GhrB -
L5504_RS01035 (218419) 218419..219081 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T234153 WP_000533909.1 NZ_CP091636:213667-214152 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T234153 NZ_LR027516:c2983550-2983227 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT234153 WP_000965889.1 NZ_CP091636:213392-213679 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT234153 NZ_LR027516:c2983875-2983630 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References