Detailed information of TA system TA234150

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4035058..4035574
• Replicon: chromosome
• Accession: NZ_CP091634
• Organism: Salmonella enterica strain 1116

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L5505_RS19375
• Protein ID: WP_133323120.1
• Coordinates: 4035058..4035342 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V7ISI8
• Locus tag: L5505_RS19380
• Protein ID: WP_000212724.1
• Coordinates: 4035332..4035574 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5505_RS19360 (4030270)	4030270..4031922	+	1653	WP_023137597.1	alpha,alpha-phosphotrehalase	-
L5505_RS19365 (4032331)	4032331..4034469	+	2139	WP_000187818.1	anaerobic ribonucleoside-triphosphate reductase	-
L5505_RS19370 (4034590)	4034590..4035054	+	465	WP_133323118.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
L5505_RS19375 (4035058)	4035058..4035342	-	285	WP_133323120.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L5505_RS19380 (4035332)	4035332..4035574	-	243	WP_000212724.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
L5505_RS19385 (4035652)	4035652..4037565	-	1914	WP_001212140.1	BglG family transcription antiterminator	-
L5505_RS19390 (4037582)	4037582..4038322	-	741	WP_023229489.1	KDGP aldolase family protein	-
L5505_RS19395 (4038319)	4038319..4039437	-	1119	WP_133323122.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
L5505_RS19400 (4039421)	4039421..4040554	-	1134	WP_133323124.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10926.73 Da
• Isoelectric Point: 9.8739

>T234150 WP_133323120.1 NZ_CP091634:c4035342-4035058 [Salmonella enterica]
MTYELEFDPRALKEWHKLDDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T234150 NZ_LR027516:2876867-2877244 [Mycobacterium tuberculosis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT234150 WP_000212724.1 NZ_CP091634:c4035574-4035332 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT234150 NZ_LR027516:2876613-2876870 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCATCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A5H5JRI5