Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3342080..3342700 Replicon chromosome
Accession NZ_CP091634
Organism Salmonella enterica strain 1116

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag L5505_RS16200 Protein ID WP_001280991.1
Coordinates 3342482..3342700 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag L5505_RS16195 Protein ID WP_000344807.1
Coordinates 3342080..3342454 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5505_RS16185 (3337219) 3337219..3338412 + 1194 WP_126524221.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L5505_RS16190 (3338435) 3338435..3341584 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
L5505_RS16195 (3342080) 3342080..3342454 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
L5505_RS16200 (3342482) 3342482..3342700 + 219 WP_001280991.1 HHA domain-containing protein Toxin
L5505_RS16205 (3342879) 3342879..3343430 + 552 WP_001278793.1 maltose O-acetyltransferase -
L5505_RS16210 (3343546) 3343546..3344016 + 471 WP_000136183.1 YlaC family protein -
L5505_RS16215 (3344072) 3344072..3344212 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
L5505_RS16220 (3344218) 3344218..3344478 - 261 WP_115276046.1 type B 50S ribosomal protein L31 -
L5505_RS16225 (3344703) 3344703..3346253 + 1551 WP_000213138.1 EAL domain-containing protein -
L5505_RS16235 (3346484) 3346484..3346873 + 390 WP_000961285.1 MGMT family protein -
L5505_RS16240 (3346906) 3346906..3347475 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T234146 WP_001280991.1 NZ_CP091634:3342482-3342700 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T234146 NZ_LR027516:c2411835-2411518 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT234146 WP_000344807.1 NZ_CP091634:3342080-3342454 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT234146 NZ_LR027516:c2412047-2411832 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References