Detailed information of TA system TA234137

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1008805..1009619
• Replicon: chromosome
• Accession: NZ_CP091634
• Organism: Salmonella enterica strain 1116

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A8E5IG67
• Locus tag: L5505_RS04800
• Protein ID: WP_000971651.1
• Coordinates: 1008805..1009332 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: L5505_RS04805
• Protein ID: WP_000855694.1
• Coordinates: 1009329..1009619 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5505_RS04770 (1005079)	1005079..1005477	+	399	Protein_935	cytoplasmic protein	-
L5505_RS04775 (1005668)	1005668..1005907	+	240	Protein_936	hypothetical protein	-
L5505_RS04780 (1006064)	1006064..1006732	+	669	WP_000445914.1	hypothetical protein	-
L5505_RS04785 (1006759)	1006759..1007253	+	495	WP_020899151.1	hypothetical protein	-
L5505_RS04790 (1007425)	1007425..1008081	-	657	WP_023181885.1	protein-serine/threonine phosphatase	-
L5505_RS04795 (1008314)	1008314..1008732	+	419	Protein_940	transposase	-
L5505_RS04800 (1008805)	1008805..1009332	-	528	WP_000971651.1	GNAT family N-acetyltransferase	Toxin
L5505_RS04805 (1009329)	1009329..1009619	-	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
L5505_RS04810 (1010213)	1010213..1010539	+	327	WP_000393295.1	hypothetical protein	-
L5505_RS04815 (1010812)	1010812..1011159	-	348	WP_001555786.1	DUF1493 family protein	-
L5505_RS04820 (1011144)	1011144..1011593	-	450	WP_133322517.1	hypothetical protein	-
L5505_RS04825 (1012025)	1012025..1012468	-	444	WP_000715096.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
L5505_RS04830 (1012925)	1012925..1013575	+	651	WP_001728903.1	type III secretion system transcriptional activator InvF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	invH / invF / invG / invE / invA / invB	1007425..1018888	11463
	-	flank	IS/Tn	-	-	1008556..1008732	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 18970.77 Da
• Isoelectric Point: 9.3905

>T234137 WP_000971651.1 NZ_CP091634:c1009332-1008805 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGGYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T234137 NZ_LR027516:c2205656-2205327 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT234137 WP_000855694.1 NZ_CP091634:c1009619-1009329 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT234137 NZ_LR027516:c2206030-2205653 [Mycobacterium tuberculosis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A3V8SJE7