Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 842499..843159 Replicon chromosome
Accession NZ_CP091634
Organism Salmonella enterica strain 1116

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Y0E4E4
Locus tag L5505_RS04055 Protein ID WP_000244757.1
Coordinates 842746..843159 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag L5505_RS04050 Protein ID WP_000351186.1
Coordinates 842499..842765 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5505_RS04030 (838427) 838427..839860 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
L5505_RS04035 (840019) 840019..840330 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
L5505_RS04040 (840494) 840494..841153 + 660 WP_000250289.1 hemolysin III family protein -
L5505_RS04045 (841269) 841269..842249 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
L5505_RS04050 (842499) 842499..842765 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
L5505_RS04055 (842746) 842746..843159 + 414 WP_000244757.1 protein YgfX Toxin
L5505_RS04060 (843212) 843212..843733 - 522 WP_001055885.1 flavodoxin FldB -
L5505_RS04065 (843846) 843846..844742 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
L5505_RS04070 (844766) 844766..845479 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L5505_RS04075 (845485) 845485..847218 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16282.29 Da        Isoelectric Point: 11.1741

>T234136 WP_000244757.1 NZ_CP091634:842746-843159 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISRQH

Download         Length: 414 bp

>T234136 NZ_LR027516:1974658-1974906 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT234136 WP_000351186.1 NZ_CP091634:842499-842765 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT234136 NZ_LR027516:1974446-1974658 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y0E4E4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References