Detailed information of TA system TA234131

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4040344..4040860
• Replicon: chromosome
• Accession: NZ_CP091630
• Organism: Salmonella enterica strain 1147

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L5506_RS19395
• Protein ID: WP_133323120.1
• Coordinates: 4040344..4040628 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V7ISI8
• Locus tag: L5506_RS19400
• Protein ID: WP_000212724.1
• Coordinates: 4040618..4040860 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5506_RS19380 (4035556)	4035556..4037208	+	1653	WP_023137597.1	alpha,alpha-phosphotrehalase	-
L5506_RS19385 (4037617)	4037617..4039755	+	2139	WP_000187818.1	anaerobic ribonucleoside-triphosphate reductase	-
L5506_RS19390 (4039876)	4039876..4040340	+	465	WP_133323118.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
L5506_RS19395 (4040344)	4040344..4040628	-	285	WP_133323120.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L5506_RS19400 (4040618)	4040618..4040860	-	243	WP_000212724.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
L5506_RS19405 (4040938)	4040938..4042851	-	1914	WP_001212140.1	BglG family transcription antiterminator	-
L5506_RS19410 (4042868)	4042868..4043608	-	741	WP_023229489.1	KDGP aldolase family protein	-
L5506_RS19415 (4043605)	4043605..4044723	-	1119	WP_133323122.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
L5506_RS19420 (4044707)	4044707..4045840	-	1134	WP_133323124.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10926.73 Da
• Isoelectric Point: 9.8739

>T234131 WP_133323120.1 NZ_CP091630:c4040628-4040344 [Salmonella enterica]
MTYELEFDPRALKEWHKLDDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T234131 NZ_LR027516:1554122-1554943 [Mycobacterium tuberculosis]
GTGGTGGTAGCCCTCGTAGGCTCAGCAATCGTGGACTTGCATTCACGACCACCGTGGTCGAACAACGCGGTGCGTCGTCT
TGGCGTGGCACTGCGCGACGGAGTTGACCCGCCGGTCGACTGCCCGTCGTACGCCGAGGTGATGCTGTGGCATGCGGACT
TGGCCGCCGAAGTCCAGGACCGGATCGAGGGCCGGAGTTGGTCTGCGTCGGAGTTATTGGTTACCTCACGTGCGAAGAGC
CAAGACACCCTGCTAGCAAAGCTGCGGCGTCGGCCTTACCTGCAACTGAACACCATCCAAGACATCGCAGGTGTCCGCAT
CGATGCCGACCTCCTGCTGGGCGAGCAGACGAGACTTGCTCGCGAGATCGCCGACCACTTCGGTGCTGACCAGCCCGCTA
TTCATGATCTGCGTGACCACCCGCACGCCGGCTACCGGGCCGTTCATGTCTGGCTTCGGTTACCTGCCGGTCGTGTCGAG
ATACAGATTCGCACCATTTTGCAGAGCCTGTGGGCCAACTTCTACGAGCTTCTCGCTGACGCGTACGGTCGGGGCATCCG
CTATGACGAGCGGCCGGAGCAGCTAGCGGCCGGCGTTGTCCCGGCACAGCTTCAAGAGCTGGTAGGGGTTATGCAAGACG
CTTCAGCGGATCTGGCGATGCATGAAGCCGAGTGGCAACACTGTGCAGAGATCGAATACCCCGGCCAGCGGGCGATGGCG
CTTGGCGAGGCGAGCAAGAACAAGGCGACGGTGCTCGCAACGACCAAGTTTAGGCTGGAAAGGGCCATCAATGAGGCCGA
GTCGGCAGGGGGAGGTGGGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT234131 WP_000212724.1 NZ_CP091630:c4040860-4040618 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT234131 NZ_LR027516:1554936-1555172 [Mycobacterium tuberculosis]
GTGGGTGAGGTGGCTGGCTATGTCGTCGAATACAACCGGCGCACCCACGTGCGTCGCATCACCGAGTTCGCCACCCCGCA
AGAAGCGATGGAGCACCGGTTGAAGCTGGAAGCCGAGCGCACCGACAGCAATATCGAGATCGTTGCGCTCGTCAGTAAGT
CGTTGGGAACCCTGAAGCAAACGCATTCGCGGTACTTCACTGGTGAAGAGCTGAACGTCGGAAACGGCGCGCGGTAG

Structures

Antitoxin

• AlphaFold DB: A0A5H5JRI5