Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 58595..59145 Replicon chromosome
Accession NC_011750
Organism Escherichia coli IAI39

Toxin (Protein)


Gene name ccdB Uniprot ID A0A0H3MLP2
Locus tag ECIAI39_RS00265 Protein ID WP_001160965.1
Coordinates 58831..59145 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1NMQ0
Locus tag ECIAI39_RS00260 Protein ID WP_000125568.1
Coordinates 58595..58828 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECIAI39_RS00235 53669..53956 + 288 WP_000203741.1 ferredoxin-like protein FixX -
ECIAI39_RS00240 54014..55345 + 1332 WP_001183201.1 MFS transporter -
ECIAI39_RS00245 55453..55983 + 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
ECIAI39_RS00250 55976..57838 + 1863 WP_000377135.1 glutathione-regulated potassium-efflux system protein KefC -
ECIAI39_RS00255 58030..58509 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
ECIAI39_RS00260 58595..58828 + 234 WP_000125568.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
ECIAI39_RS00265 58831..59145 + 315 WP_001160965.1 CcdB family protein Toxin
ECIAI39_RS00270 59142..59990 - 849 WP_000257195.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
ECIAI39_RS00275 59997..60374 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
ECIAI39_RS00280 60377..61198 - 822 WP_001065381.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
ECIAI39_RS00285 61195..62184 - 990 WP_000241224.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
ECIAI39_RS00290 62184..63470 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11725.75 Da        Isoelectric Point: 9.0851

>T23413 WP_001160965.1 NC_011750:58831-59145 [Escherichia coli IAI39]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLIDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T23413 NC_011750:58831-59145 [Escherichia coli IAI39]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAATC
CAATCCTTTTACTGATAGATGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8560.55 Da        Isoelectric Point: 5.8062

>AT23413 WP_000125568.1 NC_011750:58595-58828 [Escherichia coli IAI39]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENTEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT23413 NC_011750:58595-58828 [Escherichia coli IAI39]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACA
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3MLP2

Antitoxin

Source ID Structure
AlphaFold DB A0A829GEF2

References