Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3347368..3347988 Replicon chromosome
Accession NZ_CP091630
Organism Salmonella enterica strain 1147

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag L5506_RS16220 Protein ID WP_001280991.1
Coordinates 3347770..3347988 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag L5506_RS16215 Protein ID WP_000344807.1
Coordinates 3347368..3347742 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5506_RS16205 (3342507) 3342507..3343700 + 1194 WP_126524221.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L5506_RS16210 (3343723) 3343723..3346872 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
L5506_RS16215 (3347368) 3347368..3347742 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
L5506_RS16220 (3347770) 3347770..3347988 + 219 WP_001280991.1 HHA domain-containing protein Toxin
L5506_RS16225 (3348167) 3348167..3348718 + 552 WP_001278793.1 maltose O-acetyltransferase -
L5506_RS16230 (3348834) 3348834..3349304 + 471 WP_000136183.1 YlaC family protein -
L5506_RS16235 (3349360) 3349360..3349500 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
L5506_RS16240 (3349506) 3349506..3349766 - 261 WP_115276046.1 type B 50S ribosomal protein L31 -
L5506_RS16245 (3349991) 3349991..3351541 + 1551 WP_000213138.1 EAL domain-containing protein -
L5506_RS16255 (3351772) 3351772..3352161 + 390 WP_000961285.1 MGMT family protein -
L5506_RS16260 (3352194) 3352194..3352763 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T234127 WP_001280991.1 NZ_CP091630:3347770-3347988 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T234127 NZ_LR027516:c1245068-1244757 [Mycobacterium tuberculosis]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACACCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT234127 WP_000344807.1 NZ_CP091630:3347368-3347742 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT234127 NZ_LR027516:c1245388-1245068 [Mycobacterium tuberculosis]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References