Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5002290..5003125 Replicon chromosome
Accession NC_011748
Organism Escherichia coli 55989

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2S4A272
Locus tag EC55989_RS24955 Protein ID WP_001094443.1
Coordinates 5002748..5003125 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7LDN9
Locus tag EC55989_RS24950 Protein ID WP_001285607.1
Coordinates 5002290..5002658 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC55989_RS24915 4998182..4998862 + 681 WP_001282919.1 WYL domain-containing protein -
EC55989_RS24920 4999010..4999687 + 678 WP_001097301.1 hypothetical protein -
EC55989_RS24925 4999693..4999926 + 234 WP_001278287.1 DUF905 family protein -
EC55989_RS24930 5000016..5000834 + 819 WP_001175163.1 DUF945 domain-containing protein -
EC55989_RS24935 5000926..5001411 + 486 WP_000206664.1 antirestriction protein -
EC55989_RS24940 5001426..5001902 + 477 WP_001186165.1 RadC family protein -
EC55989_RS24945 5001989..5002210 + 222 WP_000692350.1 DUF987 domain-containing protein -
EC55989_RS24950 5002290..5002658 + 369 WP_001285607.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EC55989_RS24955 5002748..5003125 + 378 WP_001094443.1 TA system toxin CbtA family protein Toxin
EC55989_RS24960 5003122..5003610 + 489 WP_000761685.1 hypothetical protein -
EC55989_RS24965 5003630..5003827 + 198 WP_001327226.1 DUF957 domain-containing protein -
EC55989_RS29375 5003912..5004058 + 147 WP_001290178.1 hypothetical protein -
EC55989_RS24970 5004471..5005397 - 927 WP_000142493.1 site-specific integrase -
EC55989_RS24975 5005387..5007006 - 1620 WP_001223819.1 helicase/relaxase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14058.97 Da        Isoelectric Point: 7.3523

>T23412 WP_001094443.1 NC_011748:5002748-5003125 [Escherichia coli 55989]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T23412 NC_011748:5002748-5003125 [Escherichia coli 55989]
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13689.53 Da        Isoelectric Point: 6.4669

>AT23412 WP_001285607.1 NC_011748:5002290-5002658 [Escherichia coli 55989]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT23412 NC_011748:5002290-5002658 [Escherichia coli 55989]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4A272

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0JLU8

References