Detailed information of TA system TA234118

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1014094..1014908
• Replicon: chromosome
• Accession: NZ_CP091630
• Organism: Salmonella enterica strain 1147

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A8E5IG67
• Locus tag: L5506_RS04820
• Protein ID: WP_000971651.1
• Coordinates: 1014094..1014621 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: L5506_RS04825
• Protein ID: WP_000855694.1
• Coordinates: 1014618..1014908 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5506_RS04790 (1010368)	1010368..1010766	+	399	Protein_939	cytoplasmic protein	-
L5506_RS04795 (1010957)	1010957..1011196	+	240	Protein_940	hypothetical protein	-
L5506_RS04800 (1011353)	1011353..1012021	+	669	WP_000445914.1	hypothetical protein	-
L5506_RS04805 (1012048)	1012048..1012542	+	495	WP_020899151.1	hypothetical protein	-
L5506_RS04810 (1012714)	1012714..1013370	-	657	WP_023181885.1	protein-serine/threonine phosphatase	-
L5506_RS04815 (1013603)	1013603..1014021	+	419	Protein_944	transposase	-
L5506_RS04820 (1014094)	1014094..1014621	-	528	WP_000971651.1	GNAT family N-acetyltransferase	Toxin
L5506_RS04825 (1014618)	1014618..1014908	-	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
L5506_RS04830 (1015502)	1015502..1015828	+	327	WP_000393295.1	hypothetical protein	-
L5506_RS04835 (1016101)	1016101..1016448	-	348	WP_001555786.1	DUF1493 family protein	-
L5506_RS04840 (1016433)	1016433..1016882	-	450	WP_133322517.1	hypothetical protein	-
L5506_RS04845 (1017314)	1017314..1017757	-	444	WP_000715096.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
L5506_RS04850 (1018214)	1018214..1018864	+	651	WP_001728903.1	type III secretion system transcriptional activator InvF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	invH / invF / invG / invE / invA / invB	1012714..1024177	11463
	-	flank	IS/Tn	-	-	1013845..1014021	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 18970.77 Da
• Isoelectric Point: 9.3905

>T234118 WP_000971651.1 NZ_CP091630:c1014621-1014094 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGGYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T234118 NZ_LR027516:728845-729240 [Mycobacterium tuberculosis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT234118 WP_000855694.1 NZ_CP091630:c1014908-1014618 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT234118 NZ_LR027516:728591-728845 [Mycobacterium tuberculosis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A3V8SJE7