Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3311253..3311873 Replicon chromosome
Accession NZ_CP091626
Organism Salmonella enterica strain 1165

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag L5507_RS15970 Protein ID WP_001280991.1
Coordinates 3311655..3311873 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag L5507_RS15965 Protein ID WP_000344807.1
Coordinates 3311253..3311627 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5507_RS15955 (3306392) 3306392..3307585 + 1194 WP_126524221.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L5507_RS15960 (3307608) 3307608..3310757 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
L5507_RS15965 (3311253) 3311253..3311627 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
L5507_RS15970 (3311655) 3311655..3311873 + 219 WP_001280991.1 HHA domain-containing protein Toxin
L5507_RS15975 (3312052) 3312052..3312603 + 552 WP_001278793.1 maltose O-acetyltransferase -
L5507_RS15980 (3312719) 3312719..3313189 + 471 WP_000136183.1 YlaC family protein -
L5507_RS15985 (3313245) 3313245..3313385 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
L5507_RS15990 (3313391) 3313391..3313651 - 261 WP_115276046.1 type B 50S ribosomal protein L31 -
L5507_RS15995 (3313876) 3313876..3315426 + 1551 WP_000213138.1 EAL domain-containing protein -
L5507_RS16005 (3315657) 3315657..3316046 + 390 WP_000961285.1 MGMT family protein -
L5507_RS16010 (3316079) 3316079..3316648 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T234108 WP_001280991.1 NZ_CP091626:3311655-3311873 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T234108 NZ_LR027516:375691-375993 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT234108 WP_000344807.1 NZ_CP091626:3311253-3311627 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT234108 NZ_LR027516:375467-375694 [Mycobacterium tuberculosis]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGGGCGGCCGGAAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References