Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4748563..4749364 Replicon chromosome
Accession NC_011748
Organism Escherichia coli 55989

Toxin (Protein)


Gene name yeeV Uniprot ID D3GUT5
Locus tag EC55989_RS23640 Protein ID WP_001094430.1
Coordinates 4748563..4748940 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID D3GUT4
Locus tag EC55989_RS23645 Protein ID WP_001285620.1
Coordinates 4748987..4749364 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC55989_RS23615 4744647..4746185 - 1539 WP_001187182.1 lysine decarboxylation/transport transcriptional activator CadC -
EC55989_RS23625 4746934..4747776 - 843 WP_001290187.1 DUF4942 domain-containing protein -
EC55989_RS23630 4747861..4748058 - 198 WP_000772029.1 DUF957 domain-containing protein -
EC55989_RS23635 4748078..4748566 - 489 WP_000761715.1 hypothetical protein -
EC55989_RS23640 4748563..4748940 - 378 WP_001094430.1 TA system toxin CbtA family protein Toxin
EC55989_RS23645 4748987..4749364 - 378 WP_001285620.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
EC55989_RS23650 4749444..4749665 - 222 WP_000692350.1 DUF987 domain-containing protein -
EC55989_RS23655 4749752..4750228 - 477 WP_001387238.1 RadC family protein -
EC55989_RS23660 4750244..4750717 - 474 WP_000855057.1 antirestriction protein -
EC55989_RS29340 4751059..4751184 - 126 Protein_4468 DUF945 domain-containing protein -
EC55989_RS29040 4751241..4751980 + 740 Protein_4469 IS3 family transposase -
EC55989_RS23680 4752653..4754161 + 1509 WP_001189118.1 group II intron reverse transcriptase/maturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13971.82 Da        Isoelectric Point: 6.8608

>T23410 WP_001094430.1 NC_011748:c4748940-4748563 [Escherichia coli 55989]
MNTLPDTHVREASGCPSPITIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T23410 NC_011748:c4748940-4748563 [Escherichia coli 55989]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCATCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGAATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAAGCGAAACAATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13698.52 Da        Isoelectric Point: 5.9505

>AT23410 WP_001285620.1 NC_011748:c4749364-4748987 [Escherichia coli 55989]
VSDTLPGTTPPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDVDAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV

Download         Length: 378 bp

>AT23410 NC_011748:c4749364-4748987 [Escherichia coli 55989]
GTGTCAGACACACTCCCCGGGACAACGCCTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCCGACTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCAGGT
TCAGCGACGTAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACTGGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAACCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y6M7

Antitoxin

Source ID Structure
PDB 2INW
AlphaFold DB A0A0E0Y522

References