Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4042957..4043473 Replicon chromosome
Accession NZ_CP091624
Organism Salmonella enterica strain 1382

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag L5508_RS19400 Protein ID WP_133323120.1
Coordinates 4042957..4043241 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag L5508_RS19405 Protein ID WP_000212724.1
Coordinates 4043231..4043473 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5508_RS19385 (4038169) 4038169..4039821 + 1653 WP_023137597.1 alpha,alpha-phosphotrehalase -
L5508_RS19390 (4040230) 4040230..4042368 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
L5508_RS19395 (4042489) 4042489..4042953 + 465 WP_133323118.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L5508_RS19400 (4042957) 4042957..4043241 - 285 WP_133323120.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L5508_RS19405 (4043231) 4043231..4043473 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L5508_RS19410 (4043551) 4043551..4045464 - 1914 WP_001212140.1 BglG family transcription antiterminator -
L5508_RS19415 (4045481) 4045481..4046221 - 741 WP_023229489.1 KDGP aldolase family protein -
L5508_RS19420 (4046218) 4046218..4047336 - 1119 WP_133323122.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
L5508_RS19425 (4047320) 4047320..4048453 - 1134 WP_133323124.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10926.73 Da        Isoelectric Point: 9.8739

>T234093 WP_133323120.1 NZ_CP091624:c4043241-4042957 [Salmonella enterica]
MTYELEFDPRALKEWHKLDDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T234093 NZ_LR025101:c2865717-2865614 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT234093 WP_000212724.1 NZ_CP091624:c4043473-4043231 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT234093 NZ_LR025101:2865576-2865847 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References