Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3349981..3350601 Replicon chromosome
Accession NZ_CP091624
Organism Salmonella enterica strain 1382

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag L5508_RS16225 Protein ID WP_001280991.1
Coordinates 3350383..3350601 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag L5508_RS16220 Protein ID WP_000344807.1
Coordinates 3349981..3350355 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5508_RS16210 (3345120) 3345120..3346313 + 1194 WP_126524221.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L5508_RS16215 (3346336) 3346336..3349485 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
L5508_RS16220 (3349981) 3349981..3350355 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
L5508_RS16225 (3350383) 3350383..3350601 + 219 WP_001280991.1 HHA domain-containing protein Toxin
L5508_RS16230 (3350780) 3350780..3351331 + 552 WP_001278793.1 maltose O-acetyltransferase -
L5508_RS16235 (3351447) 3351447..3351917 + 471 WP_000136183.1 YlaC family protein -
L5508_RS16240 (3351973) 3351973..3352113 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
L5508_RS16245 (3352119) 3352119..3352379 - 261 WP_115276046.1 type B 50S ribosomal protein L31 -
L5508_RS16250 (3352604) 3352604..3354154 + 1551 WP_000213138.1 EAL domain-containing protein -
L5508_RS16260 (3354385) 3354385..3354774 + 390 WP_000961285.1 MGMT family protein -
L5508_RS16265 (3354807) 3354807..3355376 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T234089 WP_001280991.1 NZ_CP091624:3350383-3350601 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T234089 NZ_LR025101:c2358723-2358529 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT234089 WP_000344807.1 NZ_CP091624:3349981-3350355 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT234089 NZ_LR025101:2358352-2358530 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References