Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 213448..214208 Replicon chromosome
Accession NZ_CP091624
Organism Salmonella enterica strain 1382

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag L5508_RS01000 Protein ID WP_000533909.1
Coordinates 213723..214208 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag L5508_RS00995 Protein ID WP_000965889.1
Coordinates 213448..213735 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5508_RS00975 (208794) 208794..210122 - 1329 WP_000200570.1 MFS transporter -
L5508_RS00980 (210310) 210310..211470 - 1161 WP_000107288.1 mandelate racemase/muconate lactonizing enzyme family protein -
L5508_RS00985 (211576) 211576..212475 + 900 WP_000462482.1 LysR family transcriptional regulator -
L5508_RS00990 (212612) 212612..213265 - 654 WP_001139163.1 LysE family translocator -
L5508_RS00995 (213448) 213448..213735 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
L5508_RS01000 (213723) 213723..214208 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
L5508_RS01005 (214580) 214580..215119 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
L5508_RS01010 (215293) 215293..215505 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
L5508_RS01015 (215793) 215793..216083 - 291 WP_000455790.1 HTH-type transcriptional regulator -
L5508_RS01020 (216522) 216522..217232 + 711 WP_000190524.1 DUF3053 domain-containing protein -
L5508_RS01025 (217282) 217282..218256 - 975 WP_000804681.1 glyoxylate/hydroxypyruvate reductase GhrB -
L5508_RS01030 (218475) 218475..219137 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T234077 WP_000533909.1 NZ_CP091624:213723-214208 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T234077 NZ_LR025101:585859-586209 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT234077 WP_000965889.1 NZ_CP091624:213448-213735 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT234077 NZ_LR025101:585614-585865 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References