Detailed information of TA system TA234061

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1008804..1009618
• Replicon: chromosome
• Accession: NZ_CP091622
• Organism: Salmonella enterica strain 1419

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A8E5IG67
• Locus tag: L5509_RS04805
• Protein ID: WP_000971651.1
• Coordinates: 1008804..1009331 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: L5509_RS04810
• Protein ID: WP_000855694.1
• Coordinates: 1009328..1009618 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5509_RS04775 (1005078)	1005078..1005476	+	399	Protein_936	cytoplasmic protein	-
L5509_RS04780 (1005667)	1005667..1005906	+	240	Protein_937	hypothetical protein	-
L5509_RS04785 (1006063)	1006063..1006731	+	669	WP_000445914.1	hypothetical protein	-
L5509_RS04790 (1006758)	1006758..1007252	+	495	WP_020899151.1	hypothetical protein	-
L5509_RS04795 (1007424)	1007424..1008080	-	657	WP_023181885.1	protein-serine/threonine phosphatase	-
L5509_RS04800 (1008313)	1008313..1008731	+	419	Protein_941	transposase	-
L5509_RS04805 (1008804)	1008804..1009331	-	528	WP_000971651.1	GNAT family N-acetyltransferase	Toxin
L5509_RS04810 (1009328)	1009328..1009618	-	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
L5509_RS04815 (1010212)	1010212..1010538	+	327	WP_000393295.1	hypothetical protein	-
L5509_RS04820 (1010811)	1010811..1011158	-	348	WP_001555786.1	DUF1493 family protein	-
L5509_RS04825 (1011143)	1011143..1011592	-	450	WP_133322517.1	hypothetical protein	-
L5509_RS04830 (1012024)	1012024..1012467	-	444	WP_000715096.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
L5509_RS04835 (1012924)	1012924..1013574	+	651	WP_001728903.1	type III secretion system transcriptional activator InvF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	invH / invF / invG / invE / invA / invB	1007424..1018887	11463
	-	flank	IS/Tn	-	-	1008555..1008731	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 18970.77 Da
• Isoelectric Point: 9.3905

>T234061 WP_000971651.1 NZ_CP091622:c1009331-1008804 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGGYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T234061 NZ_LR025096:c3957979-3957572 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT234061 WP_000855694.1 NZ_CP091622:c1009618-1009328 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT234061 NZ_LR025096:c3958226-3957960 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A3V8SJE7