Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3448071..3448872 | Replicon | chromosome |
| Accession | NC_011748 | ||
| Organism | Escherichia coli 55989 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | D3GU15 |
| Locus tag | EC55989_RS17280 | Protein ID | WP_001094429.1 |
| Coordinates | 3448495..3448872 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | D3GU16 |
| Locus tag | EC55989_RS17275 | Protein ID | WP_001285617.1 |
| Coordinates | 3448071..3448448 (+) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EC55989_RS17245 | 3444731..3445186 | + | 456 | WP_000581502.1 | hypothetical protein | - |
| EC55989_RS17250 | 3445265..3445498 | + | 234 | WP_001119729.1 | DUF905 family protein | - |
| EC55989_RS17255 | 3445598..3446416 | + | 819 | WP_001234605.1 | DUF945 domain-containing protein | - |
| EC55989_RS17260 | 3446718..3447191 | + | 474 | WP_000855081.1 | antirestriction protein | - |
| EC55989_RS17265 | 3447207..3447683 | + | 477 | WP_001388380.1 | RadC family protein | - |
| EC55989_RS17270 | 3447770..3447991 | + | 222 | WP_000692350.1 | DUF987 domain-containing protein | - |
| EC55989_RS17275 | 3448071..3448448 | + | 378 | WP_001285617.1 | type IV toxin-antitoxin system toxin CbtA | Antitoxin |
| EC55989_RS17280 | 3448495..3448872 | + | 378 | WP_001094429.1 | TA system toxin CbtA family protein | Toxin |
| EC55989_RS28945 | 3448869..3449066 | + | 198 | Protein_3282 | hypothetical protein | - |
| EC55989_RS28950 | 3449094..3449291 | + | 198 | WP_085949090.1 | DUF957 domain-containing protein | - |
| EC55989_RS17290 | 3449376..3450218 | + | 843 | WP_001280493.1 | DUF4942 domain-containing protein | - |
| EC55989_RS17295 | 3450499..3451035 | - | 537 | WP_000942795.1 | GspM family type II secretion system protein YghD | - |
| EC55989_RS17300 | 3451037..3452215 | - | 1179 | WP_000094962.1 | type II secretion system protein GspL | - |
| EC55989_RS17305 | 3452212..3453189 | - | 978 | WP_000633238.1 | type II secretion system minor pseudopilin GspK | - |
| EC55989_RS17310 | 3453192..3453791 | - | 600 | WP_001255040.1 | type II secretion system minor pseudopilin GspJ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | pic / clbK / clpV/tssH / hcp/tssD / vipB/tssC / vipA/tssB / gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspD / gspC | 3350786..3509917 | 159131 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13856.73 Da Isoelectric Point: 6.8601
>T23406 WP_001094429.1 NC_011748:3448495-3448872 [Escherichia coli 55989]
MNTLPDTHVREASGCPSPITIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
MNTLPDTHVREASGCPSPITIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T23406 NC_011748:3448495-3448872 [Escherichia coli 55989]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCATCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCATCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 126 a.a. Molecular weight: 13715.59 Da Isoelectric Point: 6.6240
>AT23406 WP_001285617.1 NC_011748:3448071-3448448 [Escherichia coli 55989]
VSDTLPGTTPPDDNHDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV
VSDTLPGTTPPDDNHDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV
Download Length: 378 bp
>AT23406 NC_011748:3448071-3448448 [Escherichia coli 55989]
GTGTCAGACACACTCCCCGGGACAACGCCTCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAACCACCGTATAA
GTGTCAGACACACTCCCCGGGACAACGCCTCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAACCACCGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0XVU5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | D3GU16 |