Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 84084..85707 Replicon plasmid p1473-MDR
Accession NZ_CP091620
Organism Salmonella enterica strain 1473

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag L5510_RS22625 Protein ID WP_000088046.1
Coordinates 84382..85707 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag L5510_RS22620 Protein ID WP_024136327.1
Coordinates 84084..84377 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5510_RS22590 (L5510_22605) 79956..81197 + 1242 WP_001053338.1 VWA domain-containing protein -
L5510_RS22595 81288..81419 + 132 WP_000374059.1 hypothetical protein -
L5510_RS22600 (L5510_22610) 81760..82041 - 282 WP_000077926.1 hypothetical protein -
L5510_RS22605 (L5510_22615) 82091..82282 - 192 WP_000398480.1 hypothetical protein -
L5510_RS22610 (L5510_22620) 82374..82715 - 342 WP_001151575.1 hypothetical protein -
L5510_RS22615 (L5510_22625) 83088..83480 + 393 WP_000341066.1 hypothetical protein -
L5510_RS22620 (L5510_22630) 84084..84377 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
L5510_RS22625 (L5510_22635) 84382..85707 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
L5510_RS22630 (L5510_22640) 85816..86513 + 698 WP_095033700.1 IS1-like element IS1B family transposase -
L5510_RS22635 (L5510_22645) 87241..88059 + 819 WP_000193209.1 DUF4942 domain-containing protein -
L5510_RS22640 (L5510_22650) 88056..89261 + 1206 WP_001572381.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qnrS1 / sul2 - 1..172729 172729
- flank IS/Tn - - 85816..86091 275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T234057 WP_000088046.1 NZ_CP091620:84382-85707 [Salmonella enterica]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T234057 NZ_LR025096:c2774427-2774324 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT234057 WP_024136327.1 NZ_CP091620:84084-84377 [Salmonella enterica]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT234057 NZ_LR025096:2774286-2774557 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References