Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3306000..3306620 Replicon chromosome
Accession NZ_CP091619
Organism Salmonella enterica strain 1473

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag L5510_RS15960 Protein ID WP_001280991.1
Coordinates 3306402..3306620 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag L5510_RS15955 Protein ID WP_000344807.1
Coordinates 3306000..3306374 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5510_RS15945 (3301139) 3301139..3302332 + 1194 WP_126524221.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L5510_RS15950 (3302355) 3302355..3305504 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
L5510_RS15955 (3306000) 3306000..3306374 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
L5510_RS15960 (3306402) 3306402..3306620 + 219 WP_001280991.1 HHA domain-containing protein Toxin
L5510_RS15965 (3306799) 3306799..3307350 + 552 WP_001278793.1 maltose O-acetyltransferase -
L5510_RS15970 (3307466) 3307466..3307936 + 471 WP_000136183.1 YlaC family protein -
L5510_RS15975 (3307992) 3307992..3308132 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
L5510_RS15980 (3308138) 3308138..3308398 - 261 WP_115276046.1 type B 50S ribosomal protein L31 -
L5510_RS15985 (3308623) 3308623..3310173 + 1551 WP_000213138.1 EAL domain-containing protein -
L5510_RS15995 (3310404) 3310404..3310793 + 390 WP_000961285.1 MGMT family protein -
L5510_RS16000 (3310826) 3310826..3311395 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T234050 WP_001280991.1 NZ_CP091619:3306402-3306620 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T234050 NZ_LR025096:c674519-674262 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT234050 WP_000344807.1 NZ_CP091619:3306000-3306374 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT234050 NZ_LR025096:c674250-673699 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References