Detailed information of TA system TA234041

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1008877..1009691
• Replicon: chromosome
• Accession: NZ_CP091619
• Organism: Salmonella enterica strain 1473

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A8E5IG67
• Locus tag: L5510_RS04805
• Protein ID: WP_000971651.1
• Coordinates: 1008877..1009404 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: L5510_RS04810
• Protein ID: WP_000855694.1
• Coordinates: 1009401..1009691 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5510_RS04775 (1005151)	1005151..1005549	+	399	Protein_936	cytoplasmic protein	-
L5510_RS04780 (1005740)	1005740..1005979	+	240	Protein_937	hypothetical protein	-
L5510_RS04785 (1006136)	1006136..1006804	+	669	WP_000445914.1	hypothetical protein	-
L5510_RS04790 (1006831)	1006831..1007325	+	495	WP_020899151.1	hypothetical protein	-
L5510_RS04795 (1007497)	1007497..1008153	-	657	WP_023181885.1	protein-serine/threonine phosphatase	-
L5510_RS04800 (1008386)	1008386..1008804	+	419	Protein_941	transposase	-
L5510_RS04805 (1008877)	1008877..1009404	-	528	WP_000971651.1	GNAT family N-acetyltransferase	Toxin
L5510_RS04810 (1009401)	1009401..1009691	-	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
L5510_RS04815 (1010285)	1010285..1010611	+	327	WP_000393295.1	hypothetical protein	-
L5510_RS04820 (1010884)	1010884..1011231	-	348	WP_001555786.1	DUF1493 family protein	-
L5510_RS04825 (1011216)	1011216..1011665	-	450	WP_133322517.1	hypothetical protein	-
L5510_RS04830 (1012097)	1012097..1012540	-	444	WP_000715096.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
L5510_RS04835 (1012997)	1012997..1013647	+	651	WP_001728903.1	type III secretion system transcriptional activator InvF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	invH / invF / invG / invE / invA / invB	1007497..1018960	11463
	-	flank	IS/Tn	-	-	1008628..1008804	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 18970.77 Da
• Isoelectric Point: 9.3905

>T234041 WP_000971651.1 NZ_CP091619:c1009404-1008877 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGGYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T234041 NZ_LR025092:c4422284-4421916 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGTATTACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT234041 WP_000855694.1 NZ_CP091619:c1009691-1009401 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT234041 NZ_LR025092:c4422502-4422281 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCTGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3V8SJE7