Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 843276..843936 Replicon chromosome
Accession NZ_CP091619
Organism Salmonella enterica strain 1473

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Y0E4E4
Locus tag L5510_RS04065 Protein ID WP_000244757.1
Coordinates 843523..843936 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag L5510_RS04060 Protein ID WP_000351186.1
Coordinates 843276..843542 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5510_RS04040 (839204) 839204..840637 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
L5510_RS04045 (840796) 840796..841107 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
L5510_RS04050 (841271) 841271..841930 + 660 WP_000250289.1 hemolysin III family protein -
L5510_RS04055 (842046) 842046..843026 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
L5510_RS04060 (843276) 843276..843542 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
L5510_RS04065 (843523) 843523..843936 + 414 WP_000244757.1 protein YgfX Toxin
L5510_RS04070 (843989) 843989..844510 - 522 WP_001055885.1 flavodoxin FldB -
L5510_RS04075 (844623) 844623..845519 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
L5510_RS04080 (845543) 845543..846256 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L5510_RS04085 (846262) 846262..847995 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16282.29 Da        Isoelectric Point: 11.1741

>T234040 WP_000244757.1 NZ_CP091619:843523-843936 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISRQH

Download         Length: 414 bp

>T234040 NZ_LR025092:c4396313-4395966 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT234040 WP_000351186.1 NZ_CP091619:843276-843542 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT234040 NZ_LR025092:c4395966-4395673 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAAGTCTCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y0E4E4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References