Detailed information of TA system TA234039

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 317416..318003
• Replicon: chromosome
• Accession: NZ_CP091619
• Organism: Salmonella enterica strain 1473

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: L5510_RS01460
• Protein ID: WP_133322382.1
• Coordinates: 317650..318003 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: M7SDJ3
• Locus tag: L5510_RS01455
• Protein ID: WP_001520924.1
• Coordinates: 317416..317637 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5510_RS01430 (312437)	312437..313546	+	1110	WP_000822976.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-
L5510_RS01435 (313606)	313606..314532	+	927	WP_000003007.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
L5510_RS01440 (314529)	314529..315806	+	1278	WP_000803764.1	branched chain amino acid ABC transporter permease LivM	-
L5510_RS01445 (315803)	315803..316570	+	768	WP_000082083.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
L5510_RS01450 (316572)	316572..317285	+	714	WP_000416114.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
L5510_RS01455 (317416)	317416..317637	+	222	WP_001520924.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
L5510_RS01460 (317650)	317650..318003	+	354	WP_133322382.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
L5510_RS01465 (318262)	318262..319578	+	1317	WP_133322384.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
L5510_RS01470 (319683)	319683..320570	+	888	WP_000094074.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
L5510_RS01475 (320567)	320567..321412	+	846	WP_000572196.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
L5510_RS01480 (321414)	321414..322484	+	1071	WP_001646570.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	290242..323221	32979

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (1-109)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-49)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13015.16 Da
• Isoelectric Point: 6.7252

>T234039 WP_133322382.1 NZ_CP091619:317650-318003 [Salmonella enterica]
ISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALFITLLF
LKRNGISLAANPDFVDMTVDAAAGRLTLEQIVVRLRA

Nucleotide

• Length: 354 bp

>T234039 NZ_LR025092:c3964713-3964303 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8152.14 Da
• Isoelectric Point: 5.0775

>AT234039 WP_001520924.1 NZ_CP091619:317416-317637 [Salmonella enterica]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Nucleotide

• Length: 222 bp

>AT234039 NZ_LR025092:c3964960-3964694 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A6C6Z871