Detailed information of TA system TA234034

Bioinformatically predicted

Overview

TA module

• Type: III
• Classification (family/domain): toxIN/ToxN(toxin)
• Location: 4285..5013
• Replicon: plasmid p1653-2
• Accession: NZ_CP091617
• Organism: Salmonella enterica strain 1653

Toxin (Protein)

• Gene name: toxN
• Uniprot ID: A0A8B6BBN5
• Locus tag: L5511_RS23830
• Protein ID: WP_000675351.1
• Coordinates: 4285..4800 (-)
• Length: 172 a.a.

Antitoxin (RNA)

Gene name	toxI
Locus tag	-
Coordinates	4802..5013 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5511_RS23815 (257)	257..1936	+	1680	WP_241467032.1	AAA family ATPase	-
L5511_RS23820 (2173)	2173..2367	-	195	WP_001041636.1	Rop family plasmid primer RNA-binding protein	-
L5511_RS23825 (3161)	3161..3871	-	711	WP_000967645.1	hypothetical protein	-
L5511_RS23830 (4285)	4285..4800	-	516	WP_000675351.1	type III toxin-antitoxin system ToxN/AbiQ family toxin	Toxin
- (4850)	4850..4942	-	93	NuclAT_5	-	-
- (4850)	4850..4942	-	93	NuclAT_5	-	-
- (4850)	4850..4942	-	93	NuclAT_5	-	-
- (4850)	4850..4942	-	93	NuclAT_5	-	-
- (4850)	4850..4977	-	128	NuclAT_3	-	-
- (4850)	4850..4977	-	128	NuclAT_3	-	-
- (4850)	4850..4977	-	128	NuclAT_3	-	-
- (4850)	4850..4977	-	128	NuclAT_3	-	-
- (4802)	4802..5013	-	212	NuclAT_0	-	Antitoxin
- (4802)	4802..5013	-	212	NuclAT_0	-	Antitoxin
- (4802)	4802..5013	-	212	NuclAT_0	-	Antitoxin
- (4802)	4802..5013	-	212	NuclAT_0	-	Antitoxin
- (4886)	4886..5013	-	128	NuclAT_2	-	-
- (4886)	4886..5013	-	128	NuclAT_2	-	-
- (4886)	4886..5013	-	128	NuclAT_2	-	-
- (4886)	4886..5013	-	128	NuclAT_2	-	-
- (4921)	4921..5013	-	93	NuclAT_4	-	-
- (4921)	4921..5013	-	93	NuclAT_4	-	-
- (4921)	4921..5013	-	93	NuclAT_4	-	-
- (4921)	4921..5013	-	93	NuclAT_4	-	-
- (4957)	4957..5013	-	57	NuclAT_6	-	-
- (4957)	4957..5013	-	57	NuclAT_6	-	-
- (4957)	4957..5013	-	57	NuclAT_6	-	-
- (4957)	4957..5013	-	57	NuclAT_6	-	-
- (4850)	4850..5014	-	165	NuclAT_1	-	-
- (4850)	4850..5014	-	165	NuclAT_1	-	-
- (4850)	4850..5014	-	165	NuclAT_1	-	-
- (4850)	4850..5014	-	165	NuclAT_1	-	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..6431	6431

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• ToxN/AbiQ toxin (1-159)

Sequences

Toxin

Protein

• Length: 172 a.a.
• Molecular weight: 19724.66 Da
• Isoelectric Point: 6.7273

>T234034 WP_000675351.1 NZ_CP091617:c4800-4285 [Salmonella enterica]
MKFYTISSRYIEYLKGFEDKVPNSEDPNYQNPKAFIGIVLEIQGHKYLAPLTSPKPWHSTIKESSPSFFKLHENGVPENQ
LGLINLKFMIPIIEAEVSLLDLNGMPNTAYKRMLYKQLQFIRVNSDKIAEKSELLRKLVLQGKMQGTCNFSLLEEKYRDF
GKEANDTEEGE

Nucleotide

• Length: 516 bp

>T234034 NZ_LR025092:91494-91778 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 212 bp

>AT234034 NZ_CP091617:c5013-4802 [Salmonella enterica]
AGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTCAGGTGATTTGCTACCTTAAGTGCAGCTAGAAATTCAGGTGATTT
GCTACCTTTAAGTGCAGCTAGAAATTCAGGTGATTTGCTACCTTAAGTGCAGCTAGAAATTTAGGTCATTTACTACCTTA
AAGTAATACAGTAAAAGAGGCGACTACACAGTCGCCTTTTTTACGAGAAAAA

Structures

Toxin

• AlphaFold DB: A0A8B6BBN5

Antitoxin