Detailed information of TA system TA234012

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4035096..4035612
• Replicon: chromosome
• Accession: NZ_CP091611
• Organism: Salmonella enterica strain 1795

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L5512_RS19390
• Protein ID: WP_133323120.1
• Coordinates: 4035096..4035380 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V7ISI8
• Locus tag: L5512_RS19395
• Protein ID: WP_000212724.1
• Coordinates: 4035370..4035612 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5512_RS19375 (4030308)	4030308..4031960	+	1653	WP_023137597.1	alpha,alpha-phosphotrehalase	-
L5512_RS19380 (4032369)	4032369..4034507	+	2139	WP_000187818.1	anaerobic ribonucleoside-triphosphate reductase	-
L5512_RS19385 (4034628)	4034628..4035092	+	465	WP_133323118.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
L5512_RS19390 (4035096)	4035096..4035380	-	285	WP_133323120.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L5512_RS19395 (4035370)	4035370..4035612	-	243	WP_000212724.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
L5512_RS19400 (4035690)	4035690..4037603	-	1914	WP_001212140.1	BglG family transcription antiterminator	-
L5512_RS19405 (4037620)	4037620..4038360	-	741	WP_023229489.1	KDGP aldolase family protein	-
L5512_RS19410 (4038357)	4038357..4039475	-	1119	WP_133323122.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
L5512_RS19415 (4039459)	4039459..4040592	-	1134	WP_133323124.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10926.73 Da
• Isoelectric Point: 9.8739

>T234012 WP_133323120.1 NZ_CP091611:c4035380-4035096 [Salmonella enterica]
MTYELEFDPRALKEWHKLDDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T234012 NZ_LN999012:c86878-86480 [Salmonella enterica subsp. enterica serovar Typhimurium str. DT2]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT234012 WP_000212724.1 NZ_CP091611:c4035612-4035370 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT234012 NZ_LN999012:c87105-86878 [Salmonella enterica subsp. enterica serovar Typhimurium str. DT2]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Antitoxin

• AlphaFold DB: A0A5H5JRI5