Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3342118..3342738 Replicon chromosome
Accession NZ_CP091611
Organism Salmonella enterica strain 1795

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag L5512_RS16215 Protein ID WP_001280991.1
Coordinates 3342520..3342738 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag L5512_RS16210 Protein ID WP_000344807.1
Coordinates 3342118..3342492 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5512_RS16200 (3337257) 3337257..3338450 + 1194 WP_126524221.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L5512_RS16205 (3338473) 3338473..3341622 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
L5512_RS16210 (3342118) 3342118..3342492 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
L5512_RS16215 (3342520) 3342520..3342738 + 219 WP_001280991.1 HHA domain-containing protein Toxin
L5512_RS16220 (3342917) 3342917..3343468 + 552 WP_001278793.1 maltose O-acetyltransferase -
L5512_RS16225 (3343584) 3343584..3344054 + 471 WP_000136183.1 YlaC family protein -
L5512_RS16230 (3344110) 3344110..3344250 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
L5512_RS16235 (3344256) 3344256..3344516 - 261 WP_115276046.1 type B 50S ribosomal protein L31 -
L5512_RS16240 (3344741) 3344741..3346291 + 1551 WP_000213138.1 EAL domain-containing protein -
L5512_RS16250 (3346522) 3346522..3346911 + 390 WP_000961285.1 MGMT family protein -
L5512_RS16255 (3346944) 3346944..3347513 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T234008 WP_001280991.1 NZ_CP091611:3342520-3342738 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T234008 NZ_LN997848:4562093-4562275 [Magnetospirillum sp. XM-1]
ATGTGCGACCGGCTGACGGTCAGCCCGACACCCGACAACGGCCTGCGCAAGGTGTCCCAGATCATGGTGGACAAGACCAT
GACGGTGAATCGGGACAAACTGGGAGAGGTGTTCGGGCGGATCGACGATGGAACCATGGTTGCGGTCAACAGGGCGTTGG
CGCTGTTTCTGGGATTTGCATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT234008 WP_000344807.1 NZ_CP091611:3342118-3342492 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT234008 NZ_LN997848:4562334-4562615 [Magnetospirillum sp. XM-1]
GTGAGCAGCCTGAAAGACCTGAAGGAGCGCCTGCTTGCCGACCCGGCGACCAGGGCCGAATACGAGGCCCAGCCCCCCGA
ATTCGAGATCGCCGAGGAACTGATCCGCGCCCGCCAGCGGGCCGGGCTGTCCCAGGCCGAGGTGGCGCGCCGCATGGGCA
CCACCCAATCGGTGGTGGCCCGCCTGGAAAGCGGCCGCTCCATGCCCTCCGCCGCCTCCCTGTCCCGCTACGCCGCTGCC
ACCGGCAGCAGGCTGCATGTGGAACTGGTTCCTGCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References