Detailed information of TA system TA233999

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1008811..1009625
• Replicon: chromosome
• Accession: NZ_CP091611
• Organism: Salmonella enterica strain 1795

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A8E5IG67
• Locus tag: L5512_RS04810
• Protein ID: WP_000971651.1
• Coordinates: 1008811..1009338 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: L5512_RS04815
• Protein ID: WP_000855694.1
• Coordinates: 1009335..1009625 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5512_RS04780 (1005085)	1005085..1005483	+	399	Protein_937	cytoplasmic protein	-
L5512_RS04785 (1005674)	1005674..1005913	+	240	Protein_938	hypothetical protein	-
L5512_RS04790 (1006070)	1006070..1006738	+	669	WP_000445914.1	hypothetical protein	-
L5512_RS04795 (1006765)	1006765..1007259	+	495	WP_020899151.1	hypothetical protein	-
L5512_RS04800 (1007431)	1007431..1008087	-	657	WP_023181885.1	protein-serine/threonine phosphatase	-
L5512_RS04805 (1008320)	1008320..1008738	+	419	Protein_942	transposase	-
L5512_RS04810 (1008811)	1008811..1009338	-	528	WP_000971651.1	GNAT family N-acetyltransferase	Toxin
L5512_RS04815 (1009335)	1009335..1009625	-	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
L5512_RS04820 (1010219)	1010219..1010545	+	327	WP_000393295.1	hypothetical protein	-
L5512_RS04825 (1010818)	1010818..1011165	-	348	WP_001555786.1	DUF1493 family protein	-
L5512_RS04830 (1011150)	1011150..1011599	-	450	WP_133322517.1	hypothetical protein	-
L5512_RS04835 (1012031)	1012031..1012474	-	444	WP_000715096.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
L5512_RS04840 (1012931)	1012931..1013581	+	651	WP_001728903.1	type III secretion system transcriptional activator InvF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	invH / invF / invG / invE / invA / invB	1007431..1018894	11463
	-	flank	IS/Tn	-	-	1008562..1008738	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 18970.77 Da
• Isoelectric Point: 9.3905

>T233999 WP_000971651.1 NZ_CP091611:c1009338-1008811 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGGYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T233999 NZ_LN908249:c730255-729866 [Actinobacillus pleuropneumoniae serovar 8]
ATGTATATGCTAGATACTAATACGGTGAGTTATTTCTTTAGGCAAGATCCTACTGTGGTTAAGAAACTACAACAACTTAA
TCCGGAATTGATTTGTATTTCATCGGTCACGGCTGCAGAGTTGTTTTATGGCGTAAAAAAACGTAATAATCAGAAACTTA
CTGCATTTTTAAATACTTTTTTATCTGCGATTACGGTGATGGATTGGGATTATCAAGTGGCGGAAGTTTATGGTCAGCTG
CGAGCAGAGATGGAACGAGAAGGCAAAATCATGGGCGTTCAAGATCAAATGATTGGAGCTCATGCCCTAGCAACAGAATG
TGTTCTTGTTTCCAGCGATAAAGCCTTTCAATTTATCCCTAATCTCGTATTAGAAAATTGGTGGAAGTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT233999 WP_000855694.1 NZ_CP091611:c1009625-1009335 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT233999 NZ_LN908249:c730516-730256 [Actinobacillus pleuropneumoniae serovar 8]
ATGGAAAAGGTCGCACGTTTATTTAGAAACGGACGTAATCAAGCCGTACGATTACCGGTTGAATTTGAGTTTAATGCGAA
GCAAGTTTATGTGTTTAAAGAAGCAAACGGCGATATTACGCTTTCGACACGTTCTCGCAATCAGCAAAATTGGCAGAAAG
TCTTTGAGTTATTACCAATGCTTGAATGTGATGAACAGTTTTTATCGGAACAAGAACGCAAGCAAGAAATGGCAACTCGA
GATCCGTTCGAGGGCTTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A3V8SJE7