Detailed information of TA system TA233993

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4042999..4043515
• Replicon: chromosome
• Accession: NZ_CP091607
• Organism: Salmonella enterica strain 1810

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L5513_RS19410
• Protein ID: WP_133323120.1
• Coordinates: 4042999..4043283 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V7ISI8
• Locus tag: L5513_RS19415
• Protein ID: WP_000212724.1
• Coordinates: 4043273..4043515 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5513_RS19395 (4038211)	4038211..4039863	+	1653	WP_023137597.1	alpha,alpha-phosphotrehalase	-
L5513_RS19400 (4040272)	4040272..4042410	+	2139	WP_000187818.1	anaerobic ribonucleoside-triphosphate reductase	-
L5513_RS19405 (4042531)	4042531..4042995	+	465	WP_133323118.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
L5513_RS19410 (4042999)	4042999..4043283	-	285	WP_133323120.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L5513_RS19415 (4043273)	4043273..4043515	-	243	WP_000212724.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
L5513_RS19420 (4043593)	4043593..4045506	-	1914	WP_001212140.1	BglG family transcription antiterminator	-
L5513_RS19425 (4045523)	4045523..4046263	-	741	WP_023229489.1	KDGP aldolase family protein	-
L5513_RS19430 (4046260)	4046260..4047378	-	1119	WP_133323122.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
L5513_RS19435 (4047362)	4047362..4048495	-	1134	WP_133323124.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10926.73 Da
• Isoelectric Point: 9.8739

>T233993 WP_133323120.1 NZ_CP091607:c4043283-4042999 [Salmonella enterica]
MTYELEFDPRALKEWHKLDDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T233993 NZ_LN907827:2293862-2294149 [Erwinia gerundensis]
ATGGGCTATACAATTAAAATCAGGGAAGAGGCGCTGAAAGAATGGAATGGGCTCGACAGCATCATTCGTGAGCAGTTTAA
AAAGAAGCTCAAAAAGCCGCCTGAAAATCCGCACATCCCTGCAGCACGGTTAGCCGGTATGCCAGACTGCTATAAAATCA
AGCTCAGGGCATCCGGCTTCAGGTTGGTTTATCAGGTGATGGATGATGTGCTGATTGTCGCCGTGGTCGCGGTAGGTAAA
CGAGAGCGTAGCCAGCCCTATAAGCTGGCGAGCGAAAGATTACGTTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT233993 WP_000212724.1 NZ_CP091607:c4043515-4043273 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT233993 NZ_LN907827:2293608-2293856 [Erwinia gerundensis]
ATGGCTAATCTTATCCTTAGTGATACCAGCGCGAGTGTCAGCGAGCTGAAAAAAAACCCCATGGCTACCGTTGAAGCCGG
TGCCGGCATGCCAGTGACGATTCTTAACCGAAACCAACCCGTATTCTATTGTGTGCCTGCGCATCTGTACGAAAAAATGC
TTGAAATCATTGACGATCAGGAGCTGGCAACGCTAGTAAAAGCACGCGAAAATCAGCCTTTGCTTGATCTGGATTTGGAT
TTGGACTGA

Structures

Antitoxin

• AlphaFold DB: A0A5H5JRI5