Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3350023..3350643 Replicon chromosome
Accession NZ_CP091607
Organism Salmonella enterica strain 1810

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag L5513_RS16230 Protein ID WP_001280991.1
Coordinates 3350425..3350643 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag L5513_RS16225 Protein ID WP_000344807.1
Coordinates 3350023..3350397 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5513_RS16215 (3345162) 3345162..3346355 + 1194 WP_126524221.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L5513_RS16220 (3346378) 3346378..3349527 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
L5513_RS16225 (3350023) 3350023..3350397 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
L5513_RS16230 (3350425) 3350425..3350643 + 219 WP_001280991.1 HHA domain-containing protein Toxin
L5513_RS16235 (3350822) 3350822..3351373 + 552 WP_001278793.1 maltose O-acetyltransferase -
L5513_RS16240 (3351489) 3351489..3351959 + 471 WP_000136183.1 YlaC family protein -
L5513_RS16245 (3352015) 3352015..3352155 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
L5513_RS16250 (3352161) 3352161..3352421 - 261 WP_115276046.1 type B 50S ribosomal protein L31 -
L5513_RS16255 (3352646) 3352646..3354196 + 1551 WP_000213138.1 EAL domain-containing protein -
L5513_RS16265 (3354427) 3354427..3354816 + 390 WP_000961285.1 MGMT family protein -
L5513_RS16270 (3354849) 3354849..3355418 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T233989 WP_001280991.1 NZ_CP091607:3350425-3350643 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T233989 NZ_LN901633:c4278630-4278331 [Bradyrhizobium sp.]
ATGGCAAAAGTAAAATCATTTGATGCTGCGGAGTACCTCGACAGCCCCGAGATGATTGCAGCCTATCTCACCGAAGCCTT
CGAATCCGACGATCCGTCCGCAATAACGATGGCAATCGGCGCCGTAGCCCGCTCTCAGGGCATGGGCGCCATTGCCGAAA
AGGCCGGTCTATCCCGCGAGAACTTGTATCGCTCGCTTGGCGGCGAGGCCAAACCCGAATTCGGCACTGTGATAAAAGTT
CTCCACGCCATGGGTATCAATCTTGTGGCGCAACCCCAAAGCGGAACCAAGGCGGCGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT233989 WP_000344807.1 NZ_CP091607:3350023-3350397 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT233989 NZ_LN901633:c4278933-4278634 [Bradyrhizobium sp.]
ATGCCAACGATCAAGAGAACCGACGAATTCTCTGACTGGCTTAGAAACCTGCGAGACCGGAGAGCGAAGGCGAAAATCCT
CGCCCGGATCGATCGGCTGGCGCTCGGCAATCCCGGAGACGTTGCTCCGGTCGGAGGCGGCATCAGCGAAATGAGAGTCC
ATGAGGGCGCCGGCTACCGGATCTATTACGTTGCCCCGAGGGCGAGGAGATCATTGTTCTCCTTTGCGGGGGCGATAAAG
GGCTCTCAGCCGGGGGACATAGCGTTGGCAAAGAAGATCGCGAGCGAATTGGAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References