Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3344746..3345366 Replicon chromosome
Accession NZ_CP091604
Organism Salmonella enterica strain 1902

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag L5514_RS16215 Protein ID WP_001280991.1
Coordinates 3345148..3345366 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag L5514_RS16210 Protein ID WP_000344807.1
Coordinates 3344746..3345120 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5514_RS16200 (3339885) 3339885..3341078 + 1194 WP_126524221.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L5514_RS16205 (3341101) 3341101..3344250 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
L5514_RS16210 (3344746) 3344746..3345120 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
L5514_RS16215 (3345148) 3345148..3345366 + 219 WP_001280991.1 HHA domain-containing protein Toxin
L5514_RS16220 (3345545) 3345545..3346096 + 552 WP_001278793.1 maltose O-acetyltransferase -
L5514_RS16225 (3346212) 3346212..3346682 + 471 WP_000136183.1 YlaC family protein -
L5514_RS16230 (3346738) 3346738..3346878 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
L5514_RS16235 (3346884) 3346884..3347144 - 261 WP_115276046.1 type B 50S ribosomal protein L31 -
L5514_RS16240 (3347369) 3347369..3348919 + 1551 WP_000213138.1 EAL domain-containing protein -
L5514_RS16250 (3349150) 3349150..3349539 + 390 WP_000961285.1 MGMT family protein -
L5514_RS16255 (3349572) 3349572..3350141 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T233970 WP_001280991.1 NZ_CP091604:3345148-3345366 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T233970 NZ_LN890477:4172984-4173169 [Achromobacter xylosoxidans]
ATGAAATACAGCGAATTCAAAAAATGGCTTGAGCGGCAAGGAGCGGTTTTTGTTGCGCATCGTTCCGGAAGCAGCCATTT
TCGGGTCACGTTGAACGGCGCCACGACGATCTTTCCGTACCATGGCTCCAAGGAAATGGGTAAACACCTTGAACATGAAA
TCAAGAAGCAGCTCGGATTGAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT233970 WP_000344807.1 NZ_CP091604:3344746-3345120 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT233970 NZ_LN890477:4173245-4173664 [Achromobacter xylosoxidans]
ATGCTGACCTATCCGTTCACCCTGACGCTTGATTCCAATCGCACCTGGCTCGTTCGATTTCCAGATATTCCGGAAGCGTT
GACGGTTGGTGACGACGAGCAAGAGGCCGCGATCAACGCCAGGGAAGCGCTTGAGGCTGCGCTGGAAATCTACTTTGACG
CGCGCCGCCCCATTCCGCTGCCGTCGCCCGTATCGGCGGGGCAGGCGTCGGTGACCTTGCCGGCACTGATCACCAGCAAG
GTGTTCCTGTCCAACGAGATGATCCAGCAAGGTGTGCGCAAGGCGGAGTTGGCTCGCCGCATGGGCGTGCACATGCCGCA
AGTGGATCGTCTGCTGGATGTGCGGCACGCATCCCGGATCGAGCAGGTCGAGTCGGCGTTGGAGCAGCTTGGGCGGCGCC
TGGAGGTGTCGCTGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References