Detailed information of TA system TA233961

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1011455..1012269
• Replicon: chromosome
• Accession: NZ_CP091604
• Organism: Salmonella enterica strain 1902

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A8E5IG67
• Locus tag: L5514_RS04815
• Protein ID: WP_000971651.1
• Coordinates: 1011455..1011982 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: L5514_RS04820
• Protein ID: WP_000855694.1
• Coordinates: 1011979..1012269 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5514_RS04785 (1007729)	1007729..1008127	+	399	Protein_938	cytoplasmic protein	-
L5514_RS04790 (1008318)	1008318..1008557	+	240	Protein_939	hypothetical protein	-
L5514_RS04795 (1008714)	1008714..1009382	+	669	WP_000445914.1	hypothetical protein	-
L5514_RS04800 (1009409)	1009409..1009903	+	495	WP_020899151.1	hypothetical protein	-
L5514_RS04805 (1010075)	1010075..1010731	-	657	WP_023181885.1	protein-serine/threonine phosphatase	-
L5514_RS04810 (1010964)	1010964..1011382	+	419	Protein_943	transposase	-
L5514_RS04815 (1011455)	1011455..1011982	-	528	WP_000971651.1	GNAT family N-acetyltransferase	Toxin
L5514_RS04820 (1011979)	1011979..1012269	-	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
L5514_RS04825 (1012863)	1012863..1013189	+	327	WP_000393295.1	hypothetical protein	-
L5514_RS04830 (1013462)	1013462..1013809	-	348	WP_001555786.1	DUF1493 family protein	-
L5514_RS04835 (1013794)	1013794..1014243	-	450	WP_133322517.1	hypothetical protein	-
L5514_RS04840 (1014675)	1014675..1015118	-	444	WP_000715096.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
L5514_RS04845 (1015575)	1015575..1016225	+	651	WP_001728903.1	type III secretion system transcriptional activator InvF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	invH / invF / invG / invE / invA / invB	1010075..1021538	11463
	-	flank	IS/Tn	-	-	1011206..1011382	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 18970.77 Da
• Isoelectric Point: 9.3905

>T233961 WP_000971651.1 NZ_CP091604:c1011982-1011455 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGGYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T233961 NZ_LN890335:4060329-4060514 [Achromobacter xylosoxidans]
ATGAAATACAGCGAATTCAAAAAATGGCTTGAGCGGCAAGGAGCGGTTTTTGTTGCGCATCGTTCCGGAAGCAGCCATTT
TCGGGTCACGTTGAACGGCGCCACGACGATCTTTCCGTACCATGGCTCCAAGGAAATGGGTAAACACCTTGAACATGAAA
TCAAGAAGCAGCTCGGATTGAAATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT233961 WP_000855694.1 NZ_CP091604:c1012269-1011979 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT233961 NZ_LN890335:4060590-4061009 [Achromobacter xylosoxidans]
ATGCTGACCTATCCGTTCACCCTGACGCTTGATTCCAATCGCACCTGGCTCGTTCGATTTCCAGATATTCCGGAAGCGTT
GACGGTTGGTGACGACGAGCAAGAGGCCGCGATCAACGCCAGGGAAGCGCTTGAGGCTGCGCTGGAAATCTACTTTGACG
CGCGCCGCCCCATTCCGCTGCCGTCGCCCGTATCGGCGGGGCAGGCGTCGGTGACCTTGCCGGCACTGATCACCAGCAAG
GTGTTCCTGTCCAACGAGATGATCCAGCAAGGTGTGCGCAAGGCGGAGTTGGCTCGCCGCATGGGCGTGCACATGCCGCA
AGTGGATCGTCTGCTGGATGTGCGGCACGCATCCCGGATCGAGCAGGTCGAGTCGGCGTTGGAGCAGCTTGGGCGGCGCC
TGGAGGTGTCGCTGGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A3V8SJE7