Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 113693..114444 Replicon plasmid pR886_1
Accession NZ_CP091602
Organism Klebsiella pneumoniae strain Nord77_R886

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag L5469_RS28195 Protein ID WP_014386536.1
Coordinates 113693..114175 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag L5469_RS28200 Protein ID WP_004902250.1
Coordinates 114166..114444 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5469_RS28175 (L5469_28180) 110093..110740 - 648 WP_014386537.1 EcsC family protein -
L5469_RS28180 (L5469_28185) 110928..111521 - 594 WP_225736407.1 DUF2971 domain-containing protein -
L5469_RS28185 (L5469_28190) 111622..112014 - 393 WP_032442757.1 hypothetical protein -
L5469_RS28190 (L5469_28195) 112119..112658 - 540 WP_004902239.1 hypothetical protein -
L5469_RS28195 (L5469_28200) 113693..114175 - 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
L5469_RS28200 (L5469_28205) 114166..114444 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
L5469_RS28205 (L5469_28210) 114563..114775 - 213 WP_004902255.1 hypothetical protein -
L5469_RS28210 (L5469_28215) 114883..115224 - 342 WP_004902257.1 hypothetical protein -
L5469_RS28215 (L5469_28220) 116054..116512 - 459 WP_014386535.1 hypothetical protein -
L5469_RS28220 (L5469_28225) 117164..117619 - 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
L5469_RS28225 (L5469_28230) 117691..118056 + 366 WP_004200999.1 mercuric ion transporter MerT -
L5469_RS28230 (L5469_28235) 118072..118347 + 276 WP_000732275.1 mercury resistance system periplasmic binding protein MerP -
L5469_RS28235 (L5469_28240) 118375..118800 + 426 WP_000522996.1 organomercurial transporter MerC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid dfrA14 / blaOXA-1 / aac(6')-Ib-cr / qnrB1 / blaNDM-1 / aph(3')-VI / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 / blaCTX-M-15 / aac(6')-Ib / blaTEM-1A / tet(D) - 1..298468 298468


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T233956 WP_014386536.1 NZ_CP091602:c114175-113693 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

>T233956 NZ_LN890331:1106031-1106312 [Leuconostoc gelidum subsp. gasicomitatum KG16-1]
ATGTACAAAGTTAGACAGTCAAATCAGTTCAAAAAATCAGTTAAACGTGTTGTGAAGCAAGGAAAAGACCTTGATAAATT
ATTTCATATTGTTGACCTTATTTTAAGCGGTGATCCACTGCCGGCTCACTATAAAGACCATGTTTTAAATGGAAAAAAAT
GGCACGGCATTAGAGAATTACACATTGAGCCAGATTGGCTCCTTGCTTATCAGATAGACAATGGCGAACTTGTCCTATTA
CTCGTTGACACGGGTTCTCATTCACAAATGTTAGGTATGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT233956 WP_004902250.1 NZ_CP091602:c114444-114166 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp

>AT233956 NZ_LN890331:1105772-1106044 [Leuconostoc gelidum subsp. gasicomitatum KG16-1]
ATGACAACACAAAAAAAAGCCAATTTAAACGTAAAAATTGATCCACAACTCAAAACAGAAGCCGAAACTATCTTTGAAGA
CATGGGATTAACAACAACCGCAGCAGTTAATATGTTCATTAAACGTGTGATTGATGATAGAGAGCTACCCTTTAAACCAA
GAGTGACATCAACACTTGATAAAGCGCTTGATGATATTGAAAACAACCGTGTTGAAACCTATGATACGGCAGCAGACTGG
AAAGCATCGTTAAAAGAATATGTACAAAGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References