Detailed information of TA system TA233945

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3115170..3116758
• Replicon: chromosome
• Accession: NZ_CP091601
• Organism: Klebsiella pneumoniae strain Nord77_R886

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: L5469_RS16360
• Protein ID: WP_004179815.1
• Coordinates: 3115436..3116758 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: L5469_RS16355
• Protein ID: WP_004176198.1
• Coordinates: 3115170..3115436 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5469_RS16330 (3110320)	3110320..3111243	+	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-
L5469_RS16335 (3111224)	3111224..3112378	-	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
L5469_RS16340 (3112724)	3112724..3114103	+	1380	WP_004179808.1	nucleobase:cation symporter-2 family protein	-
L5469_RS16345 (3114081)	3114081..3114581	+	501	WP_004179811.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
L5469_RS16350 (3114578)	3114578..3114904	+	327	WP_002904788.1	hydroxyisourate hydrolase	-
L5469_RS16355 (3115170)	3115170..3115436	+	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
L5469_RS16360 (3115436)	3115436..3116758	+	1323	WP_004179815.1	type II toxin-antitoxin system HipA family toxin	Toxin
L5469_RS16365 (3116775)	3116775..3118067	-	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
L5469_RS16370 (3118209)	3118209..3119213	-	1005	WP_004179822.1	fimbrial protein	-
L5469_RS16375 (3119201)	3119201..3121702	-	2502	WP_004179823.1	fimbria/pilus outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T233945 WP_004179815.1 NZ_CP091601:3115436-3116758 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T233945 NZ_LN879429:812278-812610 [Bartonella henselae]
ATGAAGCGGGGCGAAATTTGGCTTGTATCTCTTGACCCAACTTCAGGCTATGAACAAAAAGGAACGCGTCCTGTATTGAT
TGTATCACCAGAGGCGTTTAATCGTGTCACGAAAACACCCATTGTCTTACCCATTACAAGTGGAGGAAATTTTTCTCGAA
CCGCAGGTTTCGCTGTCTCATTGGTAGGAACAGGATTGCATACAACAGGTGTGATACGTTGTGACCAGCCACGTGCTCTG
GATATAGCAGCGCGTCAGGGTAAGAAAATGGAAACAGTTCCCCCCATAATTATGAATGAAGTTCTTGCTAAGCTATCAAC
ATTTCTCACATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT233945 WP_004176198.1 NZ_CP091601:3115170-3115436 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT233945 NZ_LN879429:812021-812278 [Bartonella henselae]
ATGCACACAACAAAATTACGTAAAGTTGGAGGGTCTGTTATGCTCTCTATACCGCCGGCATTGCTTGATGTTCTTCATCT
TACTGAGAACACGCAAGTTGGTTTGGCTGTTGATAATGGACAATTGGTTGTGAAGCCACAGACATTTCCAAGTTACACTC
TTGATGAATTGTTAGCTCAATGTCATCTTTCAGATGATTTCTCTGATGAGGATATGGAGTGGTTTGATGCTAAACCTGTT
GGTAGAGAGCTCTTGTGA