Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1742586..1743205 Replicon chromosome
Accession NZ_CP091601
Organism Klebsiella pneumoniae strain Nord77_R886

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag L5469_RS09770 Protein ID WP_002892050.1
Coordinates 1742586..1742804 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag L5469_RS09775 Protein ID WP_002892066.1
Coordinates 1742831..1743205 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5469_RS09735 (1738633) 1738633..1738896 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
L5469_RS09740 (1738896) 1738896..1739036 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
L5469_RS09745 (1739033) 1739033..1739731 - 699 WP_004178762.1 GNAT family protein -
L5469_RS09750 (1739832) 1739832..1741283 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
L5469_RS09755 (1741258) 1741258..1741728 - 471 WP_002892026.1 YlaC family protein -
L5469_RS09760 (1741749) 1741749..1741889 + 141 WP_004147370.1 hypothetical protein -
L5469_RS09765 (1741861) 1741861..1742427 - 567 WP_002892030.1 maltose O-acetyltransferase -
L5469_RS09770 (1742586) 1742586..1742804 - 219 WP_002892050.1 HHA domain-containing protein Toxin
L5469_RS09775 (1742831) 1742831..1743205 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
L5469_RS09780 (1743691) 1743691..1746837 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
L5469_RS09785 (1746860) 1746860..1748053 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T233943 WP_002892050.1 NZ_CP091601:c1742804-1742586 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T233943 NZ_LN879429:c413284-413084 [Bartonella henselae]
ATGGAACAAAATAGCCGAAAGATAATTGCAAAATTAAAACGCGATGGCTTTGAACTTGTCAAAGTAAAAGGTTCGCACCA
TAAATTTAAAAAAGATGGTAAGGTTGTTATTGTCCCACATCCTAAAAAAAATCTTCCAATTGGTACAGCGCGTTCTATTG
CACAACAAGCAGGCTGGTTTAAAAAAGGAGAAGAAGAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT233943 WP_002892066.1 NZ_CP091601:c1743205-1742831 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT233943 NZ_LN879429:c413087-412692 [Bartonella henselae]
ATGAAAAGATTTTTTGCTCTTGTTCATAAAGATGAGGATTCTGCTTTTGGTGTTCAATTTCCTGATTTTGAAGGTCTATT
CTCTGCTGCTGATGAAGAAGAAAATCTTATCATAAATGCAACCGAAGCTTTGCAACTTTACTGTGAAGATATGGATACAG
TGCCTGTTCCTTTAAAATTTGAAGAAGTGATACAACAGAAAGCTGTCAAAAAAGCTTTGTCAGAAGGAGCTTTTTTAATA
CAAGTTCCTTTTATTGAAAATGATTCAGAAGTCGTACGTACAAATATATCAATTGAACGAGGGCTTTTGCGTGCAATTGA
TAATTGTGCACAAGAGAGAGGGTTAACAAGATCTGCTTTTTTGGCAACAGCAGCCCGTCACGAGCTTAATATTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References