233942

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1147828..1148638 Replicon chromosome
Accession NZ_CP091601
Organism Klebsiella pneumoniae strain Nord77_R886

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag L5469_RS06935 Protein ID WP_004178461.1
Coordinates 1148105..1148638 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag L5469_RS06930 Protein ID WP_002887278.1
Coordinates 1147828..1148094 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5469_RS06910 (1143700) 1143700..1144044 - 345 WP_004197273.1 cation efflux system protein CusF -
L5469_RS06915 (1144062) 1144062..1145447 - 1386 WP_004178457.1 efflux transporter outer membrane subunit -
L5469_RS06920 (1145619) 1145619..1146302 + 684 WP_002887273.1 copper response regulator transcription factor CusR -
L5469_RS06925 (1146292) 1146292..1147725 + 1434 WP_004178459.1 Cu(+)/Ag(+) sensor histidine kinase -
L5469_RS06930 (1147828) 1147828..1148094 + 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
L5469_RS06935 (1148105) 1148105..1148638 + 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
L5469_RS06940 (1148686) 1148686..1149807 - 1122 WP_002887282.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T233942 WP_004178461.1 NZ_CP091601:1148105-1148638 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T233942 NZ_LN879429:407358-407639 [Bartonella henselae]
ATGCGGACGATTGAACGTACGACTATCTTCAAACGTGATTTCAAGCGTGAGATGAAAGGACAACATCGGCATCTTTTAGA
TACTGATTTACGCAAAGTCATCGCAGCATTAGCAAACGATCAACCTTTAGAGATACGGTACCGTGATCATGCATTGACTG
GAAATTGGAGTAATTACCGAGATTGTCATATTCGACCTGATCTAGTGTTGATTTATCGCTTGATTGGTCAAGATAGGCTA
GTTTTAGTGCGTCTTGGTTCTCATTCACAACTTGATCTTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT233942 WP_002887278.1 NZ_CP091601:1147828-1148094 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT233942 NZ_LN879429:407108-407371 [Bartonella henselae]
ATGGCTACCAGTCGCATGGTTCAAGCACGTGTACCGGAAGAAATTCAAAATGTCGCTAGTCAAGTTATTCAAGCTTCAGG
TTTGACAGTGAGTGATGTTGTGAGGGTATTGATGACTCGTATCGCGCAAGATAAAGCTATTCCATCTGTTTTGTTTCAAC
CCAATGCAGAAACCATAGCAGCTTTTGCTGAAGTTGATGAAGGCAACTTAAAAAAGTTTCATTCCGTAGACGAATTATTT
GATGATCTTTATGCGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLZ1

References