Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1037555..1038071 Replicon chromosome
Accession NZ_CP091601
Organism Klebsiella pneumoniae strain Nord77_R886

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag L5469_RS06495 Protein ID WP_004178374.1
Coordinates 1037787..1038071 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag L5469_RS06490 Protein ID WP_002886901.1
Coordinates 1037555..1037797 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5469_RS06475 (1033583) 1033583..1034323 + 741 WP_002886899.1 KDGP aldolase family protein -
L5469_RS06480 (1034390) 1034390..1035544 + 1155 WP_004178372.1 lactonase family protein -
L5469_RS06485 (1035567) 1035567..1037477 + 1911 WP_004178373.1 PRD domain-containing protein -
L5469_RS06490 (1037555) 1037555..1037797 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L5469_RS06495 (1037787) 1037787..1038071 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L5469_RS06500 (1038075) 1038075..1038539 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L5469_RS06505 (1038780) 1038780..1040918 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
L5469_RS06510 (1041275) 1041275..1042018 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
L5469_RS06515 (1042021) 1042021..1042194 - 174 WP_032408826.1 hypothetical protein -
L5469_RS06520 (1042279) 1042279..1042587 + 309 WP_004178377.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T233941 WP_004178374.1 NZ_CP091601:1037787-1038071 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T233941 NZ_LN879429:406071-406385 [Bartonella henselae]
ATGATACATAAAAGAACGAATGAAGGTGACTTGGTAATTGAATCTTTTGCGGATAAGCGGTGTAAAGATCTTTTAGAAGG
CAATCCACCTAAAGGTTTTCCCACAACTCTCGTGCGTATAGTCCAACGAAAATTATTTATGCTGGATAAAGCAGTTGATC
TCAAAGATTTACGCAGTCCTCCGGGTAATCGTTTAGAGGCATTGAAAGGAGAGCGTAAAGGTCAATATTCTATTCGTATT
AATGACCAGTTTCGCATTTGTTTTGAGTGGCGTTCTAATGGTGCCTATGAAGTTGAAATCGTCGATTATCATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT233941 WP_002886901.1 NZ_CP091601:1037555-1037797 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT233941 NZ_LN879429:406402-406698 [Bartonella henselae]
ATGAAAAATTATATTGCTATTCATCCCGGAGAAATTTTACGGGAAGAATATTTAAAAGAATATGCTCTCTCTGCTTATGC
TCTTGCCAAAGCCTTGAATGTTCCACGCACTCGGATAGAACGGATTGTAGCAGAAAATAGTCGGATAACTCCTGATACAG
CACTACGATTAGCCTCTTTTTTTGATACAACAGCTGAATTCTGGCTCAACATGCAAGCTGCTTACGATGTCAGTGTCTTA
CAAGCTGAAAAAGCAGATGAATTTTCCAAAATTAGTAAATTTGAATGTAGAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References