Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 5055401..5056020 Replicon chromosome
Accession NZ_CP091594
Organism Klebsiella pneumoniae strain Nord5-1_R48

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag L5467_RS27795 Protein ID WP_002892050.1
Coordinates 5055802..5056020 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag L5467_RS27790 Protein ID WP_002892066.1
Coordinates 5055401..5055775 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5467_RS27780 (5050553) 5050553..5051746 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L5467_RS27785 (5051769) 5051769..5054915 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
L5467_RS27790 (5055401) 5055401..5055775 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
L5467_RS27795 (5055802) 5055802..5056020 + 219 WP_002892050.1 HHA domain-containing protein Toxin
L5467_RS27800 (5056183) 5056183..5056749 + 567 WP_002892030.1 maltose O-acetyltransferase -
L5467_RS27805 (5056721) 5056721..5056861 - 141 WP_004147370.1 hypothetical protein -
L5467_RS27810 (5056882) 5056882..5057352 + 471 WP_020802585.1 YlaC family protein -
L5467_RS27815 (5057327) 5057327..5058778 - 1452 WP_004183206.1 PLP-dependent aminotransferase family protein -
L5467_RS27820 (5058879) 5058879..5059577 + 699 WP_023287311.1 GNAT family protein -
L5467_RS27825 (5059574) 5059574..5059714 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
L5467_RS27830 (5059714) 5059714..5059977 - 264 WP_032432663.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T233934 WP_002892050.1 NZ_CP091594:5055802-5056020 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T233934 NZ_LN871187:c143854-143573 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGAGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT233934 WP_002892066.1 NZ_CP091594:5055401-5055775 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT233934 NZ_LN871187:c144078-143851 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGACCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References