Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 2525210..2525853 Replicon chromosome
Accession NZ_CP091594
Organism Klebsiella pneumoniae strain Nord5-1_R48

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag L5467_RS15355 Protein ID WP_032433387.1
Coordinates 2525437..2525853 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag L5467_RS15350 Protein ID WP_001261276.1
Coordinates 2525210..2525440 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5467_RS15335 (2520232) 2520232..2521319 + 1088 Protein_2357 transcriptional repressor PifC -
L5467_RS15340 (2521322) 2521322..2523562 + 2241 WP_045326788.1 P-loop NTPase fold protein -
L5467_RS15345 (2524090) 2524090..2524905 - 816 WP_032433388.1 hypothetical protein -
L5467_RS15350 (2525210) 2525210..2525440 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L5467_RS15355 (2525437) 2525437..2525853 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
L5467_RS15360 (2526009) 2526009..2526989 + 981 WP_032433385.1 hypothetical protein -
L5467_RS15365 (2527184) 2527184..2528755 - 1572 WP_032433383.1 AAA family ATPase -
L5467_RS15370 (2529074) 2529074..2529322 + 249 WP_032433382.1 hypothetical protein -
L5467_RS15375 (2529381) 2529381..2529899 + 519 WP_045326794.1 hypothetical protein -
L5467_RS15380 (2529930) 2529930..2530421 + 492 WP_032433378.1 hypothetical protein -
L5467_RS15385 (2530481) 2530481..2530684 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2509846..2553580 43734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T233923 WP_032433387.1 NZ_CP091594:2525437-2525853 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

>T233923 NZ_LN868938:c584950-584534 [Nocardia farcinica]
GTGATCATCCTCGACACCAACGTCATCAGCGAACCCACCACCAAGGCCCCCGACGAACGGGTCATGGCATGGCTCGACGC
CCAAGTCAGCGAAACCCTGTACCTGTCGGCCGTCACCGTCGGCGAACTCCGCTACGGCATCGCGACCATGCCTAGCGGGC
GCCGCCGCGACGAGTTCACCGACTGGCTGGAGAACCACACCCTGCCCGCGTTCACCGGCCGCATCCTGGCCTACGACCTG
AATGCCACCACGGAATACGCCCGCCTGATGTCGCAGGCCCGCGCTCAGGGGCTCGCAATCGCCGTCGCCGACGGCATGAT
CGCCGCCACCGCGGCCGCCGCAGGCTTCGCCGTCGCCACCCGCGACCGGTCACCGTTCGAGGCAGCCGATGTGCCCACTA
TCGACCCCTGGCACTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT233923 WP_001261276.1 NZ_CP091594:2525210-2525440 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT233923 NZ_LN868938:c585204-584947 [Nocardia farcinica]
ATGAAGAACGTGACGATCCGGAATCTGAGCGACGAAGTACACCGCGCCATCCGCCAACGCGCGGCCGCCAACGAACGCAG
CATCGAAGCCGAGATGCGCGCCATCCTCACCGAAGCGGTCAAACCGACCGAGCGGACCAAGATCGGCACACTCCTCGCAG
GCGTCATCAGCGAAGAGAGCCGGCTCACCGACGATGAACGCGACATCTACTTCGGCCGCGACCAGACCCCGCACGAGCCG
ATGGTGTTCGGCCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References