Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1907058..1907715 Replicon chromosome
Accession NZ_CP091594
Organism Klebsiella pneumoniae strain Nord5-1_R48

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag L5467_RS12375 Protein ID WP_002916310.1
Coordinates 1907305..1907715 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag L5467_RS12370 Protein ID WP_002916312.1
Coordinates 1907058..1907324 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5467_RS12345 (1902214) 1902214..1903647 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
L5467_RS12350 (1903766) 1903766..1904494 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
L5467_RS12355 (1904544) 1904544..1904855 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
L5467_RS12360 (1905019) 1905019..1905678 + 660 WP_002916317.1 hemolysin III family protein -
L5467_RS12365 (1905829) 1905829..1906812 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
L5467_RS12370 (1907058) 1907058..1907324 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
L5467_RS12375 (1907305) 1907305..1907715 + 411 WP_002916310.1 protein YgfX Toxin
L5467_RS12380 (1907722) 1907722..1908243 - 522 WP_004144730.1 flavodoxin FldB -
L5467_RS12385 (1908344) 1908344..1909240 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
L5467_RS12390 (1909263) 1909263..1909976 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L5467_RS12395 (1909982) 1909982..1911715 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T233922 WP_002916310.1 NZ_CP091594:1907305-1907715 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T233922 NZ_LN868200:479384-479773 [Acinetobacter baumannii]
TTGATCAACCATTCGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCATTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATTTATTTTGAAGGACATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGTAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT233922 WP_002916312.1 NZ_CP091594:1907058-1907324 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT233922 NZ_LN868200:479120-479377 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References