Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 498672..499188 Replicon chromosome
Accession NZ_CP091594
Organism Klebsiella pneumoniae strain Nord5-1_R48

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag L5467_RS05440 Protein ID WP_009486548.1
Coordinates 498672..498956 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag L5467_RS05445 Protein ID WP_002886901.1
Coordinates 498946..499188 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5467_RS05415 (494089) 494089..494397 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
L5467_RS05420 (494482) 494482..494655 + 174 WP_032433782.1 hypothetical protein -
L5467_RS05425 (494658) 494658..495401 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
L5467_RS05430 (495758) 495758..497896 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
L5467_RS05435 (498204) 498204..498668 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L5467_RS05440 (498672) 498672..498956 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L5467_RS05445 (498946) 498946..499188 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L5467_RS05450 (499266) 499266..501176 - 1911 WP_009486549.1 PRD domain-containing protein -
L5467_RS05455 (501199) 501199..502353 - 1155 WP_002886900.1 lactonase family protein -
L5467_RS05460 (502420) 502420..503160 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T233918 WP_009486548.1 NZ_CP091594:c498956-498672 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T233918 NZ_LN865144:c4211-3891 [Acinetobacter baumannii]
ATGTTATTTATTGAAACCAGTATTTTTACCAAGCAAATTAAAGAGCTTGTGAATGATGAAGAATATCGTCAGCTTCAGCA
GGATCTCTTGGTACAACCTGATAAGGGCGACTTAATCAAGAATGGCGGTGGCATTCGTAAAGTACGTTGTGCTCAAGGCA
ATAAGGGTAAAAGTGGCGGTATCCGGGTGATCTATTATTGGGTCACAGAAGATGATCAGATCTTTTTTCTGGTGGCTTAT
CCAAAGTCACTAAAAGATAACCTGACTGATAAAGAAACCTCGATCTTGCGTCAATTAGTGAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT233918 WP_002886901.1 NZ_CP091594:c499188-498946 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT233918 NZ_LN865144:c3898-3626 [Acinetobacter baumannii]
ATGGATAACAACTTATTTGATGACCTGGTTGCTTCAATTAAAGAAGCTGGTGCCATCAAACGCAATGAAATGAAAGCAAG
CCGAGTGACTGAGCTTGAATTACCAGATATTAAAGAAGTACGTGAGAAAACAGGCTTAACCCAGGCAGAATTCGCTGCAC
GTTTGCATATCAGCGCGAGAACGCTACAAAACTGGGAACAAGGTCGTCGCTATCCAACTGGTCCTGCAGCGACTCTAATT
CGCATTCTGGATGCCCATCCAACTCTGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References