Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4494164..4495752 Replicon chromosome
Accession NZ_CP091582
Organism Klebsiella pneumoniae strain Nord9_R85

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag L5468_RS22180 Protein ID WP_004199851.1
Coordinates 4494164..4495486 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag L5468_RS22185 Protein ID WP_002904790.1
Coordinates 4495486..4495752 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5468_RS22165 (L5468_22165) 4489229..4491730 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
L5468_RS22170 (L5468_22170) 4491718..4492722 + 1005 WP_004199852.1 fimbrial protein -
L5468_RS22175 (L5468_22175) 4492855..4494147 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
L5468_RS22180 (L5468_22180) 4494164..4495486 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
L5468_RS22185 (L5468_22185) 4495486..4495752 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
L5468_RS22190 (L5468_22190) 4496018..4496344 - 327 WP_002904788.1 hydroxyisourate hydrolase -
L5468_RS22195 (L5468_22195) 4496341..4496841 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
L5468_RS22200 (L5468_22200) 4496819..4498198 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
L5468_RS22205 (L5468_22205) 4498544..4499698 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
L5468_RS22210 (L5468_22210) 4499679..4500602 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T233910 WP_004199851.1 NZ_CP091582:c4495486-4494164 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T233910 NZ_LN854557:c1161056-1160853 [Sodalis glossinidius str. 'morsitans']
ATGAAAAAGATCGACTATTTAATGCGCTTGAGGAAGTGCAGAACGCTGGAAACCCTTGAGCGTGTGATTGAAAAAAACAA
ATATGAACTGTCCGATGACGAGCTAGAGATATTCAATTCCGCCGCCGATCATCGTCTGGCGGAACTGACGATGAACAAGC
TATACGACAAAGTACCGGTTTCCGTCTGGAAGTATGTACGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT233910 WP_002904790.1 NZ_CP091582:c4495752-4495486 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT233910 NZ_LN854557:c1161462-1161103 [Sodalis glossinidius str. 'morsitans']
ATGGATGAATATTCACCCAAACGCTACGATATTGCGCAATTGAAATACCTGTGTGAAAATCTCTATGATGAAGGCATTGC
CAGTCTGGGCAACAGCTATCATGGTTGGGTAAATGACCCAAGTTCCGCCGTCAATTTGCAGCTTAACGAATTAATTGAGC
ACATAGCGGCGAATATTGTCATCTTCAAACTTAAATACCATAATGAAAGTGAGCTTACCGATCAGGCTGAAACCTTTTTA
GACGATACTTTTACCCTGTTCAGTAGCTATGGCATCAATAATTACGATATACAGCGCTGGCGGCGCAGCCGCAGGCGTTT
ATTCGGAACATTCTCGGAGACAGAGCTCTGTACAACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References