Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1283543..1284059 Replicon chromosome
Accession NZ_CP091582
Organism Klebsiella pneumoniae strain Nord9_R85

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag L5468_RS06335 Protein ID WP_002886902.1
Coordinates 1283543..1283827 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag L5468_RS06340 Protein ID WP_002886901.1
Coordinates 1283817..1284059 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5468_RS06310 (L5468_06310) 1279027..1279290 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
L5468_RS06315 (L5468_06315) 1279420..1279593 + 174 WP_002886906.1 hypothetical protein -
L5468_RS06320 (L5468_06320) 1279596..1280339 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
L5468_RS06325 (L5468_06325) 1280696..1282834 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
L5468_RS06330 (L5468_06330) 1283075..1283539 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L5468_RS06335 (L5468_06335) 1283543..1283827 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L5468_RS06340 (L5468_06340) 1283817..1284059 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L5468_RS06345 (L5468_06345) 1284137..1286047 - 1911 WP_004152270.1 PRD domain-containing protein -
L5468_RS06350 (L5468_06350) 1286070..1287224 - 1155 WP_002886900.1 lactonase family protein -
L5468_RS06355 (L5468_06355) 1287290..1288030 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T233896 WP_002886902.1 NZ_CP091582:c1283827-1283543 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T233896 NZ_LN850107:1297017-1297364 [Alloactinosynnema sp. L-07]
ATGCGTCGCGGTGACATCCACCTGGTCGACTTGGACCCCGCGCGGGGCTCGGAGGCCAACAAGACCCGGCCCGCGGTGAT
CGTCAGCAACGACGCGGCCAACGCGGTGGCCGCCAGGACCGGCCGCGGCGTGGTCACGGTCGTGCCGATCACGTCCAACA
CCGGCCGGGTCTTCCCGTTCCAGGTGCTGCTGCCGGTCGCGTGCGGCTTGGACCTGGAGTCGAAGGCGCAGGCCGAGCAG
GTGCGGTCGGTGGCGACCACGCGGATCCGCGGGCGGATCGGCAAGGTCCCGCCCGAGTTGCTGGCTCGCCTCGACGAGGC
GCTGCGCATCCATCTCTCGTTGAGTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT233896 WP_002886901.1 NZ_CP091582:c1284059-1283817 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT233896 NZ_LN850107:1296812-1297030 [Alloactinosynnema sp. L-07]
GTGAAGCTGAGTGTGAGCCTGCCGGAGGACGATGTCCGGTTCATCGACGAGTACTCGGCGCGCGCTGAGGTCGCGTCGCG
CTCGTCGGTGATCCAGCTCGCCATCGCCAGGCTGCGCGAGTCCGAACTGCAGGACGAGTACGCCGCCGCCTTCGCCGAGT
GGGACGCGGCCGAGGACGCCGCCCTGTGGGACGTGACCGCGGCCGATGCGTCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References